摘要
目的研究腹腔镜微创手术对宫颈癌的临床疗效。方法选取宫颈癌患者92例,按照随机数字表法分为常规组(n=46)和微创组(n=46),常规组行传统开腹手术,微创组行腹腔镜微创手术。对比2组并发症发生率、围术期指标、疼痛程度、外周h1/h2细胞比例、免疫球蛋白(IgA、IgG、IgM)、应激反应[皮质醇(Cor)、生长激素(GH)、血管紧张素Ⅱ(AngⅡ)]变化。结果与常规组比较,微创组住院时间、排气时间短,且术中出血量少,清扫淋巴数量多(P<0.05);与常规组比较,术后1 d、7 d微创组外周h1/h2细胞多,且疼痛程度低(P<0.05);与常规组比较,术后7 d微创组IgA、IgG、IgM高(P<0.05);与常规组比较,术后7 d微创组GH、Cor、AngⅡ低(P<0.05);微创组并发症发生率[6.52%(3/46)]与常规组[17.39%(8/46)]比较无显著差异(P>0.05)。结论腹腔镜微创手术在宫颈癌治疗中可以改善围术期指标,减轻术后疼痛,降低对免疫功能和应激反应的影响,具有安全性。
Objective To investigate the clinical efficacy of laparoscopic minimally invasive surgery in the treatment of cervical cancer.Methods 92 cervical cancer patients were selected and divided into conventional group(n=46)and minimally invasive group(n=46)according to random digital table,conventional group received conventional laparotomy and minimally invasive group used laparoscopic minimally invasive surgery.Changes in the incidence of complications,perioperative indicators,pain degree,peripheral h1/h2 cells ratio,immunoglobulin(IgA,IgG,I g G,IgM),stress response[cortisol(Cor),growth hormone(GH),angiotensinⅡ(AngⅡ)]were compared.Results Compared with the conventional group,minimally invasive group had short hospitalization time and exhaust time,and intraoperative bleeding volume was small,number of cleaning lymph was large(P<0.05);Compared with the conventional groups,There were more peripheral h1/h2 cells in the minimally invasive group at 1d and 7d later,And it has a low degree of pain(P<0.05);Compared with the conventional groups,IgA,IgG and IgM were high in the 7d minimally invasive group(P<0.05);Comparison with the conventional groups,GH,Cor,and AngⅡwere low in the 7d postoperative minimally invasive group(P<0.05);There was no significant difference in 6.52%(3/46)compared with 17.39%(8/46)in the conventional group(P>0.05).Conclusion Laparoscopic minimally invasive surgery can improve perioperative indicators,reduce postoperative pain and reduce the effect on immune function and stress response in cervical cancer treatment.
作者
刘墨
李小侠
王媛媛
LIU Mo;LI Xiaoxia;WANG Yuanyuan(Nanyang Central Hospital,Nanyang,473000)
出处
《实用癌症杂志》
2022年第9期1512-1515,共4页
The Practical Journal of Cancer
关键词
宫颈癌
腹腔镜微创手术
并发症发生率
免疫球蛋白
疼痛程度
Cervical cancer
Minimally invasive surgery
Incidence of complications
Immunoglobulin
Degree of pain
