摘要
Objective The aim of the study is to systematically evaluate the effect of Traditional Chinese medicine(TCM)in the treatment of AIDS diarrhea.Methods The computer system was used to comprehensively search database of Wanfang(WF),VIP,and China National Knowledge Infrastructure(CNKI)for relevant literature on the application effect of Chinese medicine in the treatment of AIDs diarrhea.The retrieval time was set from January 1,2010 to August 15,2021.The documents that did not meet the inclusion criteria were eliminated,and the quality of the qualified literature was evaluated according to the improved Jadad scoring standard.The main outcome indicators were entered into the literature,and Review Manager 5.0 software was used for meta-analysis.Results Eight eligible articles were included,a total of 536 cases of AIDS diarrhea patients were included.All eight eligible articles observed the clinical efficacy of TCM in the treatment of AIDS diarrhea,among which four observed the TCM syndrome changes in the treatment of AIDS diarrhea,and four observed adverse reactions of TCM in the treatment of AIDS diarrhea.All articles were extracted for valid data.After entering all the main observation index data,the results of meta-analysis showed that the effect of TCM in the treatment of AIDS diarrhea was better,the differencewas statistically significant[MD=2.92,95%CI(1.81,4.70),p<0.001];TCM in the treatment of AIDS diarrhea was more conducive to improving the TCM syndrome scores of patients,the difference was statistically significant[MD=-2.55,95%CI(-3.37,-1.73),p<0.001];the adverse effects of TCM in the treatment of AIDS diarrhea were mild,and the difference was statistically significant[MD=1.70,95%Cl(0.48,5.97),p=0.41].Conclusion The effect of TCM in the treatment of AIDS diarrhea patients is remarkable,which can effectively improve the TCM symptom scores of patients without increasing the incidence of adverse reactions.
目的:系统评价中医治疗艾滋病腹泻的效果。方法:利用计算机系统、全面检索万方医学数据库、维普资讯、中国知网、中国生物医学文献服务系统等,检索有关中医治疗艾滋病腹泻应用效果的相关文献,检索时间设定为2010年1月1日至2021年8月15日;剔除不符合纳入标准的文献,对最终纳入符合条件的文献参照改良Jadad评分标准进行质量评估;录入文献主要结局指标,采用Review Manager 5.0软件进行Meta分析。结果:纳入符合条件文献8篇,共计536例艾滋病腹泻患者,8篇均观察中医治疗艾滋病腹泻的临床疗效,4篇观察中医治疗艾滋病腹泻的中医证候积分变化,4篇观察中医治疗艾滋病腹泻的不良反应,均可提取有效数据,将全部主要观察指标数据录入后,经Meta分析结果显示,中医治疗艾滋病腹泻效果更佳,差异有统计学意义[MD=2.92,95%CI(1.81,4.70),P<0.001];中医治疗艾滋病腹泻更有利于改善患者的中医证候积分,差异有统计学意义[MD=-2.55,95%CI(-3.37,-1.73),P<0.001];中医治疗艾滋病腹泻的不良反应轻微,差异有统计学意义[MD=1.70,95%CI(0.48,5.97),P=0.41]。结论:中医治疗艾滋病腹泻患者疗效显著,可有效改善患者的中医证候积分,且不会增加不良反应。
基金
funded by National Natural Science Foundation of China(U1604287)
National Science and Tech-nology Major Project During the“13th Five-Year”Plan Period(2017ZX10205502).
