摘要
目的:观察宣肺布津颗粒治疗原发性干燥综合征气阴两虚证的临床疗效。方法:收集原发性干燥综合征气阴两虚证患者共86例,随机分为两组,每组43例。对照组患者予硫酸羟氯喹治疗,治疗组患者在对照组基础上予宣肺布津颗粒治疗,疗程为8周,检测两组患者治疗前后白细胞计数(WBC)、血小板计数(PLT)、血沉(ESR)、C反应蛋白(CRP)、IgA、IgG、IgM、补体C3、补体C4、泪流率、唾液流率、干燥综合征疾病活动指数(ESSDAI)评分,评价中医证候积分,并评定中医证候疗效。结果:治疗组患者治疗后WBC、泪流率、唾液流率均较治疗前明显上升(P<0.01),IgA、IgG、ESR、CRP、ESSDAI评分、口干积分、眼干积分、乏力积分、关节痛积分、中医证候总积分均较治疗前明显下降(P<0.05)。对照组患者治疗后泪流率、唾液流率较治疗前上升(P<0.05),IgA、ESR、口干积分、眼干积分、关节痛积分、中医证候总积分均较治疗前明显下降(P<0.05)。治疗组患者治疗后WBC、泪流率均高于对照组(P<0.05),CRP、ESSDAI评分、口干积分、眼干积分、乏力积分、中医证候总积分均低于对照组,差异均有统计学意义(P<0.05)。治疗组总有效率为87.80%(36/41),对照组总有效率为75.61%(31/41),治疗组总有效率高于对照组,差异有统计学意义(P<0.01)。结论:在硫酸羟氯喹的基础上,宣肺布津颗粒治疗原发性干燥综合征气阴两虚证有较好临床疗效。
Objective:To observe the clinical efficacy of Xuanfei Bujin Granule on primary Sjogren’s syndrome with Qi and Yin deficiency syndrome.Methods:A total of 86 patients diagnosed with primary Sjogren’s syndrome with Qi and Yin deficiency syndrome were collected and randomly divided into two groups,with 43 patients in each group.The control group was treated only with hydroxychloroquine sulfate and treatment group was treated with Xuanfei Bujin Granule as well as hydroxychloroquine sulfate.The course was 8 weeks.White blood cell count(WBC),platelet count(PLT),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),IgA,IgG,IgM,complement C3,complement C4,tear flow rate,saliva flow rate and disease activity index of Sjogren’s syndrome(ESSDAI)scores were detected before and after treatment in two groups,and TCM syndrome scores were evaluated to evaluate the curative effect of TCM syndrome.Results:The WBC,tear flow rate and saliva flow rate increased significantly after treatment in treatment group(P<0.01),while the lg A,lg G,ESR,CRP,ESSDAI scores,mouth dry score,eye dry score,fatigue score,arthralgia score and the total TCM syndrome decreased in treatment group(P<0.05).In the control group,the tear flow rate and saliva flow rate increased after treatment(P<0.05),while IgA,ESR,mouth dry score,eye dry score,arthralgia score and total TCM syndrome scores decreased significantly after treatment(P<0.05).The treatment group showed higher WBC and tear flow rate than control group(P<0.05),while lower CRP,ESSDAI score,mouth dry score,eyes dry score,fatigue score and TCM syndrome scores than control group,with statistically significant difference(P<0.05).The total effective rate was 87.80%(36/41)in treatment group and 75.61%(31/41)in control group.The treatment group showed higher total effective rate than control group and the difference was statistically significant(P<0.01).Conclusion:Based on hydroxychloroquine sulfate,Xuanfei Bujin Granule shows good clinical effect on primary Sjogren’s syndrome with Qi and Yin deficiency syndrome.
作者
孙美秀
程军
李晓玥
朱文
SUN Meixiu;CHENG Jun;LI Xiaoyue;ZHU Wen(The First People's Hospital of Lianyungang,Lianyungang Jiangsu 222000,China;Nanjing University of Traditional Chinese Medicine,Nanjing Jiangsu 210023,China)
出处
《中医药导报》
2022年第8期91-95,共5页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
2021年江苏省研究生科研创新计划项目(KYCX21_1682)。
关键词
原发性干燥综合征
气阴两虚证
宣肺布津颗粒
硫酸羟氯喹
临床研究
primary Sjogren’s syndrome
Qi and Yin deficiency syndrome
Xuanfei Bujin Granule
Hydroxychloroquine sulfate
clinical study
