摘要
目的:研究苄星青霉素联合匹多莫德治疗梅毒血清固定的临床疗效。方法:选取2018年1月至2020年12月于珠海市人民医院医疗集团高新医院接受治疗的56例梅毒血清固定患者为研究对象。用随机数表法将其分为对照组和观察组,每组28例患者。对照组患者单独用苄星青霉素进行治疗,观察组患者采用匹多莫德+苄星青霉素进行治疗,然后比较两种用药方案的临床治疗效果。结果:治疗后3个月、6个月、12个月,观察组的血清TRUST转阴率均显著高于对照组,差异有统计学意义(P<0.05);与治疗前相比,两组患者治疗后的外周血T淋巴细胞亚群均有所改善,且治疗后观察组患者CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)的水平均比对照组更高,CD8^(+)的水平比对照组更低,差异有统计学意义(P<0.05);与对照组相比,观察组患者的玫瑰疹消退时间、硬下疳消退时间、扁平湿疣消退时间、掌跖梅毒疹消退时间均较短,差异有统计学意义(P<0.05)。结论:采用苄星青霉素联合匹多莫德治疗梅毒血清固定的临床疗效显著,可提高TRUST转阴率,同时可缩短皮疹消退的时间。
Objective:To study the clinical efficacy of benzathine penicillin combined with pidotimod in the treatment of syphilis serum fixation.Methods:A total of 56 patients with syphilis serum fixation who were treated in Gaoxin Hospital of Zhuhai People’s Hospital Medical Group from January 2018 to December 2020 were selected as research objects.They were divided into control group and observation group by random number table method,with 28 patients in each group.Patients in the control group were treated with benzathine penicillin alone,while patients in the observation group were treated with pidotimod+benzathine penicillin.Then the clinical therapeutic effects of the two drug regimens were compared.Results:At 3,6 and 12 months after treatment,the serum TRUST conversion rate in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).Compared with before treatment,the peripheral blood T lymphocyte subsets of the two groups were improved after treatment,and the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,and the level of CD8^(+)was lower than that in the control group,the differences were statistically significant(P<0.05).Compared with the control group,the regression time of Rosetta,chancre,condyloma planus and palmoplantar syphilis in the observation group were shorter,and the differences were statistically significant(P<0.05).Conclusion:Benzathine penicillin combined with pidotimod has a significant clinical effect in the treatment of syphilis serum fixation,which can increase the rate of TRUST turning negative and shorten the time of rash resolution.
作者
李伟斌
LI Weibin(Gaoxin Hospital,Zhuhai People’s Hospital Medical Group,Zhuhai 519100)
关键词
苄星青霉素
匹多莫德
梅毒血清固定
benzathine penicillin
Pidotimod
Syphilis serum fixation
