摘要
疼痛是一种主观的、不愉快的感觉与情感体验。个体对疼痛刺激或疼痛状态的反应存在明显差异,也称为疼痛的易感与非易感。疼痛的个体差异受遗传、环境等多种因素的影响,机制复杂。本文梳理了疼痛个体差异或疼痛易感与非易感的相关概念,系统综述了疼痛个体差异的影响因素及其外周与中枢机制,提出了疼痛个体差异研究领域内存在的重要问题与挑战,并对其未来的发展方向进行了讨论与展望,以期为疼痛的基础研究与临床治疗提供新的思路。
Pain is defined as an unpleasant sensory and emotional experience.The experience of pain is characterized by tremendous inter-individual variability,a common phenomenon termed susceptibility and resilience to pain.Multiple factors,such as genetic,psychosocial,and environmental variables,contribute to the inter-individual difference in pain perception.The current paper briefly goes over concepts relative to the inter-individual differences in pain,systematically reviews currently-known contributors and possible mechanisms underlying susceptibility and resilience to pain,and proposes future challenges and research directions,hopefully introducing novel research strategies and opening up new avenues for future pain treatment.
作者
韩奕
翟晓静
陈丹丹
周瑜
周冬雨
章文欣
季然
李杞泽
高易红
曹君利
张红星
HAN Yi;ZHAI Xiaojing;CHEN Dandan;ZHOU Yu;ZHOU Dongyu;ZHANG Wenxin;JI Ran;LI Qize;GAO Yihong;CAO Junli;ZHANG Hongxing(Jiangsu Province Key Laboratory of Anesthesiology,Xuzhou Medical University,Xuzhou 221004,China;Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology,Xuzhou 221004,China;NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs,Xuzhou,221004,China;Department of Anesthesiology,The Affiliated Hospital of Xuzhou Medical University,Xuzhou,221002,China)
出处
《中国疼痛医学杂志》
CAS
CSCD
北大核心
2022年第8期571-581,共11页
Chinese Journal of Pain Medicine
基金
科技创新2030—“脑科学与类脑研究”重大项目(2021ZD0203100)
国家自然科学基金(31970937)
江苏省自然科学基金(BK 20190047)
江苏特聘教授和江苏省双创人才与双创团队项目
江苏省高等学校自然科学研究重大项目(17KJA320005)
江苏省研究生科研与实践创新计划项目(KYCX22_2918,KYCX22_2932,KYCX21_2710,KYCX21_2712,KYCX21_2715)。
关键词
疼痛
个体差异
易感
非易感
神经机制
pain
individual differences
susceptibility
resilience
neurobiological mechanism
