摘要
目的 探讨急性脑出血患者血清髓过氧化物酶(MPO)、S100钙结合蛋白A12(S100A12)、网膜素-1(Omentin-1)表达,分析其与患者神经功能损伤及预后的关系。方法 选取2017年1月至2020年1月海南省第二人民医院神经外科收治的急性脑出血患者110例(观察组),应用美国国立卫生研究院卒中量表(NIHSS)评估患者入院时神经功能损伤情况,将患者分为轻度组(<8分,25例)、中度组(8~<15分,47例)及重度组(≥15分,38例)。另选取海南省第二人民医院体检健康者80例作为对照组。采用酶联免疫吸附试验检测血清MPO、S100A12、Omentin-1水平。3个月后采用格拉斯哥预后量表(GOS)评估患者预后情况,将其分为预后不良组和预后良好组。采用多因素Logistic回归分析急性脑出血患者预后不良的影响因素。采用受试者工作特征(ROC)曲线分析血清MPO、S100A12、Omentin-1对急性脑出血患者预后不良的预测价值。结果 观察组血清MPO、S100A12水平高于对照组,血清Omentin-1水平低于对照组,差异有统计学意义(P<0.05)。不同严重程度急性脑出血患者血清MPO、S100A12、Omentin-1水平相比,差异有统计学意义(P<0.05)。预后不良组血清MPO、S100A12水平高于预后良好组,血清Omentin-1水平低于预后良好组,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果示,NIHSS评分,以及血清MPO、S100A12、Omentin-1水平是急性脑出血患者预后不良的独立影响因素(P<0.05)。ROC曲线分析结果显示,血清MPO、S100A12、Omentin-1联合检测预测急性脑出血患者预后不良的曲线下面积为0.901,灵敏度和特异度分别为0.736、0.897。结论 急性脑出血患者血清MPO、S100A12水平升高,血清Omentin-1水平降低,以上指标与患者神经功能损伤及预后不良有关。
Objective To investigate the expressions of serum myeloperoxidase(MPO),S100 calcium binding protein A12(S100 A12) and Omentin-1 in the patients with acute cerebral hemorrhage, and to analyze their relationship with neurological deficit and prognosis.Methods A total of 110 patients with acute cerebral hemorrhage admitted to the neurosurgery department of Hainan Provincial Second People′s Hospital from January 2017 to January 2020 were selected(observation group).The National Institutes of Health Stroke Scale(NIHSS) was used to assess the neurological deficit of the patients at admission, and the patients were divided into the mild group(<8 points, 25 cases),moderate group(8-<15 points, 47 cases) and severe group(≥15 points, 38 cases).Other 80 healthy people undergoing physical examination in this hospital were selected as the control group.Serum MPO,S100 A12 and Omentin-1 levels were detected by the enzyme-linked immunosorbent assay.After 3 months, the Glasgow Outcome Scale(GOS) was used to evaluate the prognosis of the patients, and the patients were divided into the poor prognosis group and good prognosis group.The multivariate Logistic regression was used to analyze the influencing factors of poor prognosis in patients with acute cerebral hemorrhage.The receiver operating characteristic(ROC) curve was used to analyze the predictive value of serum MPO,S100 A12 and Omentin-1 for the poor prognosis of the patients.Results The levels of serum MPO and S100 A12 in the observation group were higher than those in the control group, and the level of serum Omentin-1 was lower than that in the control group, and the differences were statistically significant(P<0.05).In the comparison of serum MPO,S100 A12 and Omentin-1 levels among the patients with different severities of acute cerebral hemorrhage, the differences were statistically significant(P<0.05).The serum MPO and S100 A12 levels in the poor prognosis group were higher than those in the good prognosis group, and the serum Omentin-1 level was lower than that in the good prognosis group, and the differences were statistically significant(P<0.05).The multivariate Logistic regression analysis results showed that the NIHSS score, serum MPO,S100 A12 and Omentin-1 levels were the independent influencing factors for the poor prognosis in the patients with acute cerebral hemorrhage(P<0.05).The ROC curve analysis results showed that the area under the curve of combined detection of serum MPO,S100 A12 and Omentin-1 for predicting the poor prognosis of the patients with acute cerebral hemorrhage was 0.901,the sensitivity and specificity were 0.736 and 0.897,respectively.Conclusion The levels of serum MPO and S100 A12 in the patients with acute cerebral hemorrhage are increased and the level of serum Omentin-1 is decreased, and the above indicators are related to the neurological deficit and poor prognosis of the patients.
作者
崔海随
胡德献
杨昌立
王刚
CUI Haisui;HU Dexian;YANG Changli;WANG Gang(Department of Neurosurgery,Hainan Provincial Second People's Hospital,Wuzhishan,Hainan 572299,China;Department of Neurosurgery,Second Affiliated Hospital of Hainan Medical University,Haikou,Hainan 570216,China)
出处
《国际检验医学杂志》
CAS
2022年第18期2223-2227,共5页
International Journal of Laboratory Medicine
基金
海南省自然科学基金面上项目(817399)。
