摘要
近年来,新辅助化疗在乳腺癌综合治疗中占据着越来越重要的地位,如何在治疗早期预测患者能否从中获益是当今的研究热点。凝血系统的异常激活导致的高凝状态已被证实可促进并影响恶性肿瘤的发生发展。多项研究表明,凝血功能与乳腺癌浸润、转移、预后等密切相关,抗凝剂的使用在一定程度上能降低乳腺癌患者的死亡风险。基于此,本文主要对外周血凝血相关指标与乳腺癌、乳腺癌新辅助化疗疗效预测的相关研究作一综述,以期为乳腺癌新辅助化疗预测因子的寻找提供帮助。
In recent years,neoadjuvant chemotherapy plays an increasingly important role in the comprehensive treatment of breast cancer.How to predict whether patients can benefit from it in the early stage of treatment is a research hotspot.Hypercoagulable state caused by abnormal activation of coagulation system has been proved to promote and affect the occurrence and development of malignant tumors.A number of studies have shown that coagulation function is closely related to breast cancer invasion,metastasis and prognosis.The use of anticoagulants can reduce the risk of death in breast cancer patients to a certain extent.Based on this,this article mainly reviews the related research on peripheral blood coagulation related indicators and the prediction of the efficacy of neoadjuvant chemotherapy for breast cancer and breast cancer,in order to provide help for the search for predictors of neoadjuvant chemotherapy for breast cancer.
作者
关利平
李建文
GUAN Li-ping;LI Jian-wen(Guangdong Medical University,Zhanjiang 524000,Guangdong,China)
出处
《医学信息》
2022年第16期159-162,共4页
Journal of Medical Information
关键词
乳腺癌
新辅助化疗
凝血功能
抗凝剂
Breast cancer
Neoadjuvant chemotherapy
Coagulation function
Anticoagulant
