摘要
目的比较帕利哌酮与利培酮治疗精神分裂症的临床效果。方法回顾性分析2018年2月—2020年5月平潭精神病防治院收治的112例精神分裂症患者临床资料,根据用药方案不同分为观察组和对照组,各56例。对照组予利培酮片治疗,观察组予帕利哌酮缓释片治疗。比较2组治疗效果,治疗前与治疗后1周、2周、4周血药浓度、血清泌乳素水平变化及不良反应。结果观察组患者治疗总有效率为98.21%,高于对照组的82.14%(χ^(2)=8.166,P=0.004);2组治疗后1周、2周、4周血药浓度均较治疗前下降,且观察组低于同期对照组(P均<0.01);治疗后1周、2周、4周观察组血清泌乳素水平均低于同期对照组(P均<0.01);观察组不良反应总发生率为1.78%,低于对照组的19.64%(χ^(2)=9.333,P=0.002)。结论帕利哌酮相较于利培酮治疗精神分裂症的临床效果更为显著,安全性高,通过了解药物治疗剂量、疗效、不良反应与血药浓度间的相关性为患者开展个性化与针对性治疗,实现更为科学合理的用药,利于促进患者全面康复,提升患者日常生活质量。
Objective To compare the clinical effects of paliperidone and risperidone in the treatment of schizophrenia.Methods The clinical data of 112 schizophrenic patients admitted to Pingtan Mental Health Hospital from February 2018 to May 2020 were retrospectively analyzed.They were divided into observation group and control group according to different medication schemes,with 56 cases in each group.The control group was treated with risperidone tablets,and the observation group was treated with paliperidone sustained-release tablets.The therapeutic effects,the changes of plasma drug concentration and serum prolactin level before and 1,2 and 4 weeks after treatment,and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate in the observation group was 98.21%,higher than 82.14%in the control group(χ^(2)=8.166,P=0.004).The blood drug concentration of the two groups at 1,2 and 4 weeks after treatment was lower than that before treatment,and that of the observation group was lower than that of the control group(P<0.01).The indexes of serum prolactin in the observation group were lower than those in the control group at 1,2 and 4 weeks after treatment(P<0.01).The total incidence of adverse reactions in the observation group was 1.78%,lower than 19.64%in the control group(χ^(2)=9.333,P=0.002).Conclusion Compared with risperidone,paliperidone is more effective and safe in the treatment of schizophrenia.By understanding the correlation between drug dosage,efficacy,adverse reactions and blood drug concentration,we can carry out personalized and targeted treatment for patients to achieve more scientific and rational drug use,which is conducive to promoting the comprehensive rehabilitation of patients and improving the quality of daily life of patients.
作者
许世欢
吴声辉
XU Shihuan;WU Shenghui(Psychiatry Department,Pingtan Mental Health Hospital,Fujian Province,Pingtan County 350400,China)
出处
《临床合理用药杂志》
2022年第23期17-19,23,共4页
Chinese Journal of Clinical Rational Drug Use
关键词
精神分裂症
帕利哌酮
利培酮
血药浓度
临床疗效
不良反应
Schizophrenia
Paliperidone
Risperidone
Blood drug concentration
Clinical efficacy
Adverse reactions
