摘要
近年来,随着POU家族相关基础研究的增多,发现POU结构域蛋白与细胞的发育、复制、生长和细胞周期阻滞以及分化密切相关,其中POU3F2不仅参与胚胎发育和中枢神经系统分化,还在恶性肿瘤细胞中广泛表达,并以不同的机制调节肿瘤细胞的增殖、侵袭和转移能力,进而影响肿瘤患者预后。本文就转录因子POU3F2的结构特性,以及在常见恶性肿瘤中的作用和研究进展进行阐述,探讨POU3F2与肿瘤细胞干性、肿瘤神经内分泌分化、肿瘤侵袭转移及修复损伤等的关系,并分析POU3F2在恶性肿瘤中的表达调控方式及对预后的影响,为进一步研究其在肿瘤中的调节机制提供理论基础。
In recent years,with more and more basic research on the POU family,it has been found that POU domain proteins are related to cell development,replication,growth,and cell cycle blocking and differentiation.POU3 F2 not only participates in embryonic development and differentiation of central neuroendocrine system,but also has wide expression in malignant tumors,and regulates the proliferation,invasion and metastasis of tumor cells in different ways to affect tumor development.Based on the structure of POU3 F2,the review expounds the function and research status of POU3 F2 in common malignant tumors,with the hope of further studying its mechanism and preventing diseases.
作者
马东江
邓成伍
魏成
吕秉哲
王琛
MA Dongjiang;DENG Chengwu;WEI Cheng;LYU Bingzhe;WANG Chen(Department of General Surgery,Lanzhou University Second Hospital,Lanzhou 730000,China)
出处
《协和医学杂志》
CSCD
2022年第5期858-863,共6页
Medical Journal of Peking Union Medical College Hospital
基金
甘肃省科技重大专项计划(19ZD2WA001)。
