摘要
目的研究呼吸内科住院患者抗生素临床用药情况与耐药性。方法回顾性分析130例呼吸内科住院患者的临床资料,采用药房查询系统、电子方案等分析整理患者用药情况,统计患者抗生素使用种类、抗生素联合使用情况以及细菌培养和药敏试验情况。结果呼吸内科住院患者半合成青霉素类使用率最高为36.92%,氟喹诺酮类使用率为29.23%,大环内酯类使用率为20.77%,其他抗生素使用率为13.08%。呼吸内科住院患者单一用药率最高为44.62%,二联用药率为41.54%,三联用药率为13.85%。参与细菌培养和药敏试验患者102例(78.46%)。患者病原菌为肺炎克雷伯菌、铜绿假单胞菌、大肠埃希菌及鲍曼不动杆菌,占比分别为49.02%、26.47%、15.69%、8.82%。结论呼吸内科住院患者抗生素使用率过高,多数患者长时间使用抗生素会使肺炎克雷伯菌、铜绿假单胞菌等病原菌产生耐药性,严重影响患者疾病治疗效果,因此需要呼吸内科医师重视,对患者用药方案进行调整,提升抗生素用药合理性。
Objective To study the clinical use of antibiotics and drug resistance among inpatients of respiratory medicine.Methods The clinical data of 130 inpatients of respiratory medicine were retrospective analyzed.The pharmacy query system and electronic scheme were used to analyze and organize patients'medication use,and to count the types of antibiotics,combination of antibiotics,bacterial culture and drug sensitivity tests.Results The utilization rate of semi-synthetic penicillins in hospitalized patients in respiratory medicine was 36.92%,fluoroquinolones utilization rate was 29.23%,macrolide utilization rate was 20.77%,and other antibiotics utilization rate was 13.08%.The highest rate of single medication was 44.62%,the rate of double medication was 41.54%,and the rate of triple medication was 13.85%.102 patients(78.46%)participated in bacterial culture and drug sensitivity test,and the pathogenic bacteria were Klebsiella pneumoniae,Pseudomonas aeruginosa,Escherichia coli and Acinetobacter baumannii,accounting for 49.02%,26.47%,15.69%and 8.82%,respectively.Conclusion The antibiotic usage rate of inpatients of respiratory medicine is too high,and most patients will develop resistance to pathogenic bacteria such as Klebsiella pneumoniae and Pseudomonas aeruginosa with prolonged use of antibiotics,which seriously affects the therapeutic effect of patients.Therefore,it is necessary for respiratory physicians to pay attention,adjust the patient's medication regimen,and improve the rationality of antibiotic use.
作者
韩吉明
HAN Ji-ming(Zhuanghe Central Hospital,Zhuanghe 116400,China)
出处
《中国现代药物应用》
2022年第16期183-185,共3页
Chinese Journal of Modern Drug Application
关键词
呼吸内科
住院患者
抗生素
临床用药情况
Respiratory medicine
Inpatients
Antibiotics
Clinical medication
