摘要
目的 观察接骨七厘片联合复方骨肽注射液促进腰椎压缩性骨折患者术后恢复的效果。方法 将152例行经皮椎体成形术治疗的腰椎压缩性骨折患者随机分成联合组与复方骨肽组,每组76例。两组均给予复方骨肽注射液治疗,联合组同时给予接骨七厘片治疗,疗程均为1个月。比较两组的治疗总有效率,以及手术前后的伤椎解剖结构相关指标(椎体压缩率、Cobb角、骨密度)、骨代谢指标(骨保护素、Ⅰ型胶原羧基末端肽、核因子κB受体活化因子配体)、疼痛视觉模拟量表评分。结果 联合组的治疗总有效率高于复方骨肽组(P<0.05)。两组患者术后的椎体压缩率、Cobb角、疼痛视觉模拟量表评分及血清核因子κB受体活化因子配体、Ⅰ型胶原羧基末端肽水平均低于或小于术前,骨密度及血清骨保护素水平均高于术前,且联合组上述指标均优于复方骨肽组(均P<0.05)。结论 与单纯使用复方骨肽注射液相比,采用接骨七厘片联合复方骨肽注射液治疗,可提高腰椎压缩性骨折术后患者的临床疗效,并可更有效地改善机体骨代谢,减轻患者术后疼痛。
Objective To observe the effect of Jiegu Qili Tablet combined with Compound Ossotide for Injection in the promotion of postoperative recovery in patients with lumbar vertebral compression fracture.Methods A total of 152 patients with lumbar vertebral compression fracture undergoing percutaneous vertebroplasty were randomly assigned to combination group or compound ossotide group,with 76 cases in each group.Both groups were given Compound Ossotide for Injection for treatment;simultaneously,the combination group was treated with Jiegu Qili Tablet.The treatment course lasted for one month.The total effective rate of treatment,and pre-and postoperative indices related to anatomical structure of injured vertebrae(the vertebrae compression rate,Cobb angle,bone mineral density),bone metabolic indices(osteoprotegerin,β-C-terminal telopeptide of type Ⅰ collagen,receptor activator of nuclear factor-kappa B ligand),and Visual Analogue Scale score for pain were compared between the two groups.Results The total effective rate of treatment in the combination group was higher than that in the compound ossotide group(P<0.05).The vertebral compression rate,Cobb angle,Visual Analogue Scale score for pain,and serum receptor activator of nuclear factor-kappa B ligand and β-C-terminal telopeptide of type Ⅰ collagen levels in the two groups were lower or smaller than those before operation,and the bone mineral density and serum osteoprotegerin level were higher than those before operation,and the combination group yielded superior aforementioned indices to compared with the compound ossotide group(all P<0.05).Conclusion Compared with using Compound Ossotide for Injection alone,employing Jiegu Qili Tablet combined with Compound Ossotide for Injection can improve the clinical efficacy of patients with lumbar vertebral compression fracture,more effectively ameliorate the body bone metabolism,and relieve the postoperative pain of patients.
作者
丛宝华
赵维彪
赵方
宋飞
CONG Bao-hua;ZHAO Wei-biao;ZHAO Fang;SONG Fei(Department of Orthopedic Surgery,Liaoning Jinqiu Hospital,Shenyang 110000,Liaoning,China)
出处
《广西医学》
CAS
2022年第15期1749-1752,共4页
Guangxi Medical Journal
基金
辽宁省科学技术计划项目(20180551060)。
关键词
腰椎压缩性骨折
接骨七厘片
复方骨肽注射液
经皮椎体成形术
术后
骨代谢
疼痛
疗效
Lumbar vertebral compression fracture
Jiegu Qili Tablet
Compound Ossotide for Injection
Percutaneous vertebroplasty
Post-operation
Bone metabolism
Pain
Efficacy
