摘要
目的 探讨上皮细胞钙粘附蛋白(E-cad)、基质金属蛋白酶抑制剂-2(TIMP-2)及骨桥蛋白(OPN)对甲状腺癌患者病情进展及预后的价值。方法 选取2016年5月至2018年5月北京市房山区中医医院收治的174例甲状腺癌患者(174份甲状腺癌组织标本)作为癌组织组,选取同期在本院行手术治疗的141例甲状腺瘤患者(141份甲状腺瘤组织标本)作为腺瘤组织组。比较两组E-cad、TIMP-2及OPN表达情况,分析三者与甲状腺癌患者病情进展的关系,统计随访期间甲状腺癌患者预后情况,绘制受试者工作特征曲线(ROC),评估联合E-cad、TIMP-2及OPN三者检测对甲状腺癌患者预后死亡的预测价值。结果 癌组织组E-cad阴性率及TIMP-2、OPN阳性率高于腺瘤组织组,差异均有统计学意义(P<0.05)。E-cad阴性及TIMP-2、OPN阳性的患者病理分类为乳头状癌、TNM分期为T3~T4、有淋巴结转移、肿瘤数目为多个的患者占比高于E-cad阳性及TIMP-2、OPN阴性的患者,差异有统计学意义(P<0.05)。本研究随访率100%,随访期间死亡33例(18.97%),生存141例(81.03%)。E-cad阴性表达及TIMP-2、OPN阳性表达的甲状腺癌患者死亡率显著高于E-cad阳性表达及TIMP-2、OPN阴性表达的患者,差异有统计学意义(P<0.05)。联合E-cad、TIMP-2、OPN检查对预测甲状腺癌患者预后死亡的灵敏度(0.896)、特异度(0.912)、AUC(0.988)均高于单一指标检测(P<0.05)。结论 E-cad、TIMP-2、OPN参与甲状腺癌患者病情进展的过程,临床可通过联合三项指标检测评估甲状腺癌患者预后。
Objective To investigate the value of epithelial cell cadherin(E-cad),matrix metalloproteinase inhibitor-2(TIMP-2)and osteopontin(OPN)on the progression and prognosis of patients with thyroid cancer. Methods 174 patients with thyroid cancer admitted to Beijing Fangshan Hospital of Traditional Chinese Medicine from May 2016 to May 2018 were selected as the cancer tissue group(174 thyroid cancer tissue specimens),and 141 patients with thyroid tumor who underwent surgical treatment in our hospital during the same period(141 thyroid tumor tissue specimens)were selected as the adenoma tissue group. The expressions of E-cad,TIMP-2 and OPN between the two groups were compared,and the relationship between the three and the progression of thyroid cancer patients was analyzed. The predictive value of E-cad,TIMP-2 and OPN detection in the prognosis and death of patients with thyroid cancer. Results The negative rate of E-cad and the positive rate of TIMP-2 and OPN in the cancer tissue group were higher than those in the adenoma tissue group,and the differences were statistically significant(P<0.05). The proportion of pathological classification as papillary carcinoma,TNM stage T3~T4,lymph node metastasis,and multiple tumors in patients with E-cad negative and TIMP-2,OPN positive wre higher than the proportion of patients with E-cad positive and TIMP-2,OPN-negative patients,the differences were statistically significant(P<0.05). The follow-up rate of this study was 100%,during the follow-up period,33 cases died(18.97%)and 141 cases survived(81.03%). The mortality rate of thyroid cancer patients with negative expression of E-cad,positive expression of TIMP-2 and OPN was significantly higher than that of patients with positive expression of E-cad and negative expression of TIMP-2 and OPN,the difference was statistically significant(P<0.05). The sensitivity(0.896),specificity(0.912)and AUC(0.988)of the combined E-cad,TIMP-2 and OPN examinations for predicting the prognostic death of patients with thyroid cancer were higher than that of single indicator detection(P<0.05). Conclusion E-cad,TIMP-2 and OPN are involved in the progression of thyroid cancer patients,and the clinical prognosis of thyroid cancer patients can be evaluated by combining the three indicators.
作者
白建云
张菁
刘小静
BAI Jianyun;ZHANG Jing;LIU Xiaojing(Department of General Surgery,Fangshan Hospital of Traditional Chinese Medicine,Beijing,China,102400)
出处
《分子诊断与治疗杂志》
2022年第9期1536-1540,共5页
Journal of Molecular Diagnostics and Therapy
基金
北京市自然科学基金面上项目(7182058)。
