摘要
目的探讨血清C反应蛋白(CRP)、未成熟粒细胞(IG)、碱性磷酸酶(ALP)与支原体肺炎(MPP)患儿病情和预后的关系。方法选取2019年10月至2021年12月期间安徽省皖南康复医院儿科收治的MPP患儿88例为研究对象,根据临床肺部感染评分(CPIS)及预后转归情况将患儿分为轻症组和重症组、预后良好组和预后不良组,比较分析各组上述血清指标及其与MPP患儿病情严重程度的相关性,进一步评价其对MPP患儿预后的预测效能。结果重症组MPP患儿WBC、CRP、IG、ALP水平均高于轻症组,差异均有统计学意义(P<0.05);Pearson相关检验显示,CPIS评分分别与WBC、CRP、IG、ALP水平呈轻度正相关(P<0.05);预后良好组与预后不良组在上述血清指标水平上比较,差异均有统计学意义(P<0.05);多因素Logistic回归显示,上述血清指标水平均为影响MPP患儿预后的独立危险因素(P<0.05);ROC曲线显示,MPP患儿预后预测的临界值、AUC最高为联合检测,且其敏感度为86.69%,特异性为89.66%。结论血清CRP、IG、ALP与MPP病情严重呈正相关,且其水平变化是MPP患儿预后不良的独立危险因素,动态监测可为临床医师对MPP病情严重程度及预后评估提供参考价值。
Objective To investigate the relationship between serum C-reactive protein(CRP),immature granulocytes(IG),alkaline phosphatase(ALP)and the condition and prognosis of children with mycoplasma pneumonia(MPP).Methods A total of 88 children with MPP who were admitted to the Pediatrics Department of Wannan Rehabilitation Hospital in Anhui Province from October 2019 to December 2021 were selected as the research subjects.According to the clinical pulmonary infection score(CPIS)and prognosis,the children were divided into the mild disease group,the severe disease group,the good prognosis group and the poor prognosis group.The above serum indicators and their correlation with the severity of MPP children in each group were compared and analyzed to further evaluate their predictive efficacy for the prognosis of children with MPP.Results The levels of WBC,CRP,Ig and ALP in the severe MPP group were significantly higher than those in the mild MPP group(P<0.05).The Pearson correlation test showed that CPIs score was slightly positively correlated with WBC,CRP,Ig and ALP levels(P<0.05).There were significant differences in the above serum indicator levels between the good prognosis group and the poor prognosis group(P<0.05).Multivariate logistic regression showed that the above serum indicator levels were independent risk factors affecting the prognosis of children with MPP(P<0.05).The ROC curve showed that the critical value of prognosis prediction in children with MPP and the highest AUC were combined detection,with a sensitivity of 86.69%and a specificity of 89.66%.Conclusion Serum CRP,IG,and ALP are highly expressed in children with severe MPP,which are positively correlated with the severity of MPP,and their level changes are independent risk factors for poor prognosis in children with MPP.Dynamic monitoring can provide reference value for clinicians to evaluate the severity and prognosis of MPP.
作者
吴艺
汤申红
余霞
WU Yi;TANG Shenhong;YU Xia(Department of Pediatrics,South Wannan Rehabilitation Hospital,Wuhu No.5 People's Hospital,Wuhu,Anhui,China,241000)
出处
《分子诊断与治疗杂志》
2022年第9期1566-1569,共4页
Journal of Molecular Diagnostics and Therapy
基金
芜湖市科技计划项目(2015hm10)。
关键词
未成熟粒细胞
碱性磷酸酶
C反应蛋白
肺炎
Immature granulocytes
Alkaline phosphatase
C-reactive protein
Pneumonia
