摘要
目的 探讨多囊卵巢综合征(PCOS)患者血清及卵泡液中25-羟基维生素D[25(OH)D]对体外受精-胚胎移植(IVE-ET)妊娠结局的影响。方法 选取2019年5月至2020年5月在我院生殖中心首次就诊的不孕且行IVE-ET治疗的80例PCOS患者作为研究对象,根据临床妊娠结局将其分为临床妊娠组(n=38)和临床未妊娠组(n=42)。比较两组受试者的临床资料及促排卵情况,通过ELISA法测定25(OH)D水平,通过Pearson法分析血清与卵泡液25(OH)D水平的相关性,采用Cox回归分析影响受试者妊娠结局的因素。结果 临床妊娠组患者的受精率、血清及卵泡液中25(OH)D水平都高于临床未妊娠组,差异有统计学意义(t值分别是2.236、2.446、2.893,P<0.05)。血清与卵泡液中25(OH)D水平呈正相关(r=0.981,P<0.05);Cox回归分析显示,血清和卵泡液25(OH)D是影响受试者临床妊娠结局的独立因素(HR值分别是2.874、2.338,P<0.05)。结论 PCOS患者血清及卵泡液25(OH)D水平是影响患者IVE-ET妊娠结局的独立因素。
Objective To investigate the effects of 25-hydroxyvitamin D [25(OH)D]in serum and follicular fluid of patients with polycystic ovary syndrome(PCOS) on the outcomes of in vitro fertilization-embryo transfer(IVE-ET) pregnancy.Methods 80 patients with PCOS who were infertile and treated with IVE-ET in the reproductive center of our hospital for the first time from May 2019 to May 2020 were selected as the research subjects.According to the clinical pregnancy outcomes, they were divided into the clinical pregnancy group(n=38) and the clinical non pregnancy group(n=42).The clinical data and ovulation induction of two groups were compared.25(OH)D levels were determined by ELISA.Pearson correlation was used to analyze the correlation between serum and follicular fluid 25(OH)D levels, and Cox regression was used to analyze the factors affecting the pregnancy outcomes.Results The fertilization rate, 25(OH)D levels in serum and follicular fluid in the clinical pregnancy group were significantly higher than those in the clinical non pregnancy group(t =2.236,2.446 and 2.893,respectively, P<0.05).There was a positive correlation between serum 25(OH)D level and follicular fluid 25(OH)D level(r=0.981,P<0.05);Cox regression analysis showed that serum and follicular fluid 25(OH)D were independent factors affecting the clinical pregnancy outcomes(HR=2.874 and 2.338,respectively, P<0.05).Conclusion Serum and follicular fluid 25(OH)D levels in PCOS patients were independent factors affecting pregnancy outcomes of IVE-ET.
作者
王睿
王文娟
尹正芳
郭清民
熊正方
WANG Rui;WANG Wenjuan;YIN Zhengfang;GUO Qingmin;XIONG Zhengfang(Reproductive medicine center,Qinghai Provincial People's Hospital,Qinghai Xining 810000,China;Department of Gynecology,Qinghai Provincial People's Hospital,Qinghai Xining 810000,China)
出处
《中国妇幼健康研究》
2022年第8期111-115,共5页
Chinese Journal of Woman and Child Health Research
基金
青海省卫健委医药卫生科技项目(编号:2020-wjzdx-32)。
关键词
维生素D
多囊卵巢综合征
体外受精-胚胎移植
妊娠结局
vitamin D
polycystic ovary syndrome
in vitro fertilization-embryo transfer
pregnancy outcomes
