摘要
目的探讨妊娠期高血压合并乙型肝炎(乙肝)孕妇肝功能指标变化及对妊娠结局的影响。方法选取50例妊娠期高血压孕妇为研究组,根据是否合并乙肝分为妊娠期高血压组(32例)与妊娠期高血压合并乙肝组(18例);另选取同期在医院分娩的50例健康孕妇为正常妊娠组。检测三组孕妇丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、总胆汁酸(TBA),并比较三组妊娠结局情况。结果妊娠期高血压合并乙肝组ALT、AST、TBIL及TBA指标明显高于妊娠期高血压组,而妊娠期高血压组高于正常妊娠组,差异具有统计学意义(P<0.05).妊娠期高血压合并乙肝组早产、剖宫产、产褥感染、产后出血发生率均低于妊娠期高血压组与正常妊娠组,差异有统计学意义(P<0.05),而妊娠期高血压组与正常妊娠组妊娠结局比较,差异无统计学意义(P>0.05)。结论妊娠期高血压合并乙肝孕妇肝功能损伤明显,会增加不良妊娠结局发生率。
Objective To investigate the changes of liver function indexes in pregnant women with gestational hypertension complicated with hepatitis B(HBV)and its influence on pregnancy outcome.Methods 50 pregnant women with gestational hypertension were selected as study group,and were divided into gestational hypertension group(n=32)and gestational hypertension group(n=18)according to whether they had hepatitis B or not.Another 50 healthy pregnant women who delivered in hospital during the same period were selected as normal pregnancy group.Alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),total bile acid(TBA)of pregnant women in the three groups were detected,and the pregnancy outcomes of the three groups were compared.Results The indexes of alt,AST,TBIL and TBA in pregnancy induced hypertension combined with hepatitis B group were significantly higher than those in pregnancy induced hypertension group,while those in pregnancy induced hypertension group were significantly higher than those in normal pregnancy group(P<0.05).The incidence of preterm delivery,cesarean section,puerperal infection and postpartum hemorrhage in pregnancy induced hypertension combined with hepatitis B group were significantly lower than those in pregnancy induced hypertension group and normal pregnancy group(P<0.05),but there was no significant difference in pregnancy outcome between pregnancy induced hypertension group and normal pregnancy group(P>0.05).Conclusion The liver function of pregnant women with pregnancy induced hypertension and hepatitis B is damaged obviously,which will increase the incidence of adverse pregnancy outcomes.
作者
唐琼瑛
陈秀英
Tang Qiongying;Chen Xiuying(Department of Obstetrics and Gynecology,Wanning Maternal and Child Health Hospital,Wanning 571500,China)
出处
《实用妇科内分泌电子杂志》
2022年第9期20-23,共4页
Electronic Journal of Practical Gynecological Endocrinology
关键词
妊娠期高血压
乙型肝炎
肝功能
妊娠结局
Pregnancy induced hypertension
Hepatitis B
Liver function
pregnancy outcome
