摘要
目的:研究三七总皂苷和复方苦参注射液联合化疗对急性髓系白血病(AML)的血清VEGF和LDH的影响及临床疗效观察。方法:收集急性髓系白血病患者60例,随机分为治疗组和对照组各30例。治疗组给予常规化疗方案联合注射用血栓通(冻干)和复方苦参注射液治疗,对照组给予常规化疗方案,观察治疗前后两组的临床疗效及血清VEGF和LDH水平变化。结果:治疗14 d后,治疗组有效率为83. 3%,对照组有效率为60. 0%,两组比较有显著性差异(P <0. 05)。两组患者治疗后血清LDH和VEGF较治疗前显著降低,与治疗前比较,差异有统计学意义(P <0. 05),治疗组较对照组降低更为明显,差异有统计学意义(P <0. 05)。结论:三七总皂苷和复方苦参注射液联合化疗治疗AML可提高化疗有效率,可明显降低患者血清VEGF和LDH水平。
Objective To observe the clinical observation and influence on VEGF and LDH of AML patients cured with PNS and Compound Kushen Injection combined with chemotherapy. Methods Collected 60 cases diagnosed with AML,randomly divided into treatment group and control group,each group of 30 cases,The treatment group was given PNS and Compound Kushen Injection combined withchemotherapy,and the control group was given conventional chemotherapy,observed efficacy and the levels of VEGF and LDH before and after treatment. Results After 14 days of treatment,the effective rate of treatment group was 83. 3%,and that ofthe control group was 60. 0%,two groups had obvious difference( P < 0. 05). After the treatment,the levels of VEGF and LDH in both groups were significantly decreased compared with before treatment,and the difference was statistically significant( P < 0. 05). The level of VEGF and LDH of treatment group were lower than control group,there was significant difference between two groups( P <0. 05). Conclusions The combination of PNS and Compound Kushen Injection in the treatment of AML improved the effective rate of chemotherapy,and significantly reduced the levels of VEGF and LDH in serum.
作者
孙洋馨
许洋
王彦丽
公为亮
袁从芳
伦志彩
张晓云
SUN Yangxin;XU Yang;WANG Yanli;GONG Weiliang;YUAN Congfang;LUN Zhicai;ZHANG Xiaoyun(Afflated Hospital of Shandong Academy of Traditional Chinese Medicine,Jinan 250014,China;Linyi Central Hospital,Linyi 276400,China;Juxian Hospital of Traditional Chinese Medicine,Juxian 276500,China)
出处
《中国民族民间医药》
2022年第17期97-99,118,共4页
Chinese Journal of Ethnomedicine and Ethnopharmacy
基金
山东中医药科技发展计划(编号2017-475)。
