摘要
目的观察老年冠心病合并抑郁患者应用草酸艾司西酞普兰联合阿托伐他汀钙对血脂、血清相关因子表达水平及抑郁症状的影响。方法招募2018年7月~2020年10月期间入住我科的125例老年冠心病合并抑郁患者作为研究对象,对照组62例给予阿托伐他汀钙及心理疏导治疗,观察组63例增加草酸艾司西酞普兰治疗,三个月后,对比两组患者血脂水平、血清相关因子表达水平和抑郁状况。结果治疗前及治疗后,两组患者高密度脂蛋白(HDL)、低密度脂蛋白胆固醇(LDL)、总胆固醇(TC)、甘油三酯水平(TG)表达水平无差异(P>0.05);治疗前及治疗后,两组患者肿瘤坏死因子-α(TNF-α)、白细胞介素水平(IL)、氧化应激指标丙二醛(MDA)、超氧化物歧化酶(SOD)表达水平无差异(P>0.05);治疗后,观察组患者抑郁自评量表(SDS)、老年抑郁量表(GDS)均明显低于对照组(P<0.05)。结论草酸艾司西酞普兰联合阿托伐他汀钙能够有效降低老年冠心病合并抑郁患者的血脂水平,改善患者血清相关因子表达水平,缓解患者的抑郁状态,值得临床应用。
Objective To observe the effect of escitalopram oxalate combined with atorvastatin calcium on blood lipids,serum related factors and depressive symptoms in elderly patients with coronary heart disease complicated with depression.Methods 125 elderly patients with coronary heart disease(CHD)and depression admitted to our department from July 2018 to October 2020 were recruited as the research objects.62 cases in the control group were treated with atorvastatin calcium and psychological counseling,while 63 cases in the observation group were treated with escitalopram oxalate.Blood lipid levels,serum related factor expression levels and depression status were compared between the two groups.Results Before and after treatment,there were no differences in the expression levels of high density lipoprotein(HDL),low density lipoprotein cholesterol(LDL),total cholesterol(TC)and triglyceride(TG)between the two groups(P>0.05).Before and after treatment,there were no differences in the levels of tumor necrosis factor-α(TNF-α),interleukin(IL),oxidative stress indexes malondialdehyde(MDA)and superoxide dismutase(SOD)between the two groups(P>0.05).After treatment,the self-rating Depression scale(SDS)and geriatric Depression Scale(GDS)in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Escitalopram oxalate combined with atorvastatin calcium can effectively reduce the blood lipid level,improve the expression level of serum related factors in elderly patients with coronary heart disease,and alleviate the depression of patients,which is worthy of clinical application.
作者
林烨
周建华
焦红军
LIN Ye;ZHOU Jianhua;JIAO Hongjun(Department of Pharmacy,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《国际精神病学杂志》
2022年第4期659-661,共3页
Journal Of International Psychiatry
基金
河南省医学科技攻关计划项目(编号:2018020151)。
关键词
老年冠心病
抑郁
血清相关因子水平
血脂水平
草酸艾司西酞普兰
Elderly coronary heart disease
Depression
Serum levels of related factors
Lipid levels
Escitalopram oxalate
