摘要
妊娠区带蛋白(pregnancy zone protein,PZP)是一种高度依赖雌激素的免疫血浆蛋白,含有多个蛋白酶的识别位点,是一个较好的免疫抑制剂。PZP具有独特的结构和理化性质,在生物医学领域具有重要的应用潜力。近年来,随着ELISA技术和质谱技术的发展,PZP水平在疾病中得到评估,其水平的升高已被报道与恶性疾病发生有关。该文综述了PZP在相关疾病中的研究进展,并重点阐述了其作为肿瘤的新型血清标志物的研究,以期为肿瘤的诊断提供新思路。
PZP (pregnancy zone protein) is a highly estrogen-dependent immune plasma protein,which contains multiple protease recognition sites and is an excellent immunosuppressant.PZP has unique structure,physical and chemical properties and has great potential in biomedical applications.In recent years,with the development of ELISA and mass spectrometry,PZP level has been evaluated in disease,and its elevation has been reported to be associated with malignant disease.This article reviews the research progress of PZP in related diseases,and focuses on its research as a new serum marker of tumor,in order to provide a new idea for the diagnosis of tumor.
作者
王璐
陈玲丽
黄飚
周秀梅
WANG Lu;CHEN Lingli;HUANG Biao;ZHOU Xiumei(College of Life Sciences and Medicine,Zhejiang Sci-Tech University,Hangzhou 310018,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2022年第5期866-873,共8页
Chinese Journal of Cell Biology
