摘要
目的探讨优泌乐25R对新诊断2型糖尿病血糖控制和脂代谢的影响。方法选取汕尾市第二人民医院自2018年6月—2020年8月住院新诊断的50例2型糖尿病伴血脂异常患者,对其实施2个月的优泌乐25R治疗,观察治疗前及治疗2个月后的空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血蛋白(HbA1c)的变化情况,及空腹C肽、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平的变化情况。结果治疗2个月后,患者的FPG(6.68±1.24)mmol/L、2 hPG(9.26±1.87)mmol/L、HbA1c(7.19±1.18)%、TG(1.46±0.32)mmol/L、TC(4.76±0.36)mmol/L、LDL-C(2.52±1.32)mmol/L水平明显低于治疗前,空腹C肽水平(0.83±0.54)pmol/L明显高于治疗前,差异有统计学意义(t=6.139、10.614、16.430、12.574、3.153、3.730、2.385,P<0.05)。结论优泌乐25R对新诊断2型糖尿病血糖控制和脂代谢具有积极影响,能够有效降低FPG、2 hPG、HbA1c、TG、TC、LDLC水平,并提升空腹C肽水平。
Objective To investigate the effect of Humalog 25R on blood glucose control and lipid metabolism in newly diagnosed type 2 diabetes.Methods Fifty patients with newly diagnosed type 2 diabetes mellitus with dyslipidemia who were hospitalized in Second People’s Hospital of Shanwei from June 2018 to August 2020 were selected and treated with Humalog 25R for 2 months.The changes of fasting blood glucose(FPG),2 h postprandial blood glucose(2hPG),glycated blood protein(HbA1c),fasting C-peptide,triglyceride(TG),total cholesterol(TC)and low density lipoprotein cholesterol(LDL-C)levels before treatment and after 2 months of treatment were observed.Results After 2months of treatment,the patients’FPG(6.68±1.24)mmol/L,2 hPG(9.26±1.87)mmol/L,HbA1c(7.19±1.18)%,TG(1.46±0.32)mmol/L,TC(4.76±0.36)mmol/L and LDL-C(2.52±1.32)mmol/L were significantly lower than those before treatment,the fasting C-peptide level(0.83±0.54)pmol/L was significantly higher than that before treatment,and the difference was statistically significant(t=6.139,10.614,16.430,12.574,3.153,3.730,2.385,P<0.05).Conclusion Humalog 25R has a positive effect on blood glucose control and lipid metabolism in newly diagnosed type2 diabetes,and can effectively reduce the levels of FPG,2 hPG,HbA1c,TG,TC,and LDL-C,and increase the level of fasting C-peptide.
作者
曾丰年
龚丽友
吕志威
ZENG Fengnian;GONG Liyou;LYU Zhiwei(Department of Endocrinology,Second People's Hospital of Shanwei(Shanwei Yihui Foundation Hospital),Shanwei,Guangdong Province,516600 China)
出处
《糖尿病新世界》
2022年第15期1-3,8,共4页
Diabetes New World Magazine
关键词
优泌乐25R
2型糖尿病
血糖控制
脂代谢
Humalog 25R
Type 2 diabetes
Blood glucose control
Lipid metabolism
