摘要
目前,抗生素药物的不良反应和多重耐药(MDR)菌株的出现严重威胁着人们的生命健康,迫切需要开发新的治疗细菌,尤其是耐药菌感染的方法。利用简单的化学反应制备了聚乙烯亚胺稳定的聚吡咯纳米颗粒(PPy-PEI NPs),并通过调节吡咯单体的组分获得一系列不同尺寸的纳米颗粒。采用动态光散射(DLS)、扫描电子显微镜(SEM)、透射电子显微镜(TEM)和紫外-可见吸收光谱分析了PPy-PEI NPs的物理和化学特性。此外,研究了PPy-PEI NPs对大肠杆菌(E.coli)、铜绿假单胞菌(P.aeruginosa)、金黄色葡萄球菌(S.aureus)和耐甲氧西林金黄色葡萄球菌(MRSA)的光热抗菌活性。研究结果表明,在808 nm近红外光照射下,合成的PPy-PEI NPs能够完全抑制病原菌的生长。因此,PPy-PEI NPs是优良的有机纳米光热剂,并在光热抗菌治疗领域具有良好的应用前景。
Nowadays,the adverse side effects of existing antibiotics and the development of multiple drug resistance(MDR)have a severe impact on public health.To overcome these obstacles,there is an urgent need for new antibacterial therapeutics.In this work,polyethyleneimine-stabilized polypyrrole nanoparticles(PPy-PEI NPs)with different pyrrole contents were prepared by a simple chemical reaction.The characteristics of the PPy-PEI NPs were analyzed by dynamic light scattering(DLS),scanning electron microscope(SEM),transmission electron microscope(TEM),and UV-visible absorption spectroscopic analysis.Moreover,the antibacterial photothermal activity of the PPy-PEI NPs was evaluated against E.coli,P.aeruginosa,S.aureus and Methicillin-resistant S.aureus(MRSA).Our results unveil that the synthesized PPy-PEI NPs could completely inhibit the growth of bacterial pathogens under 808 near-infrared light irradiation.Therefore,PPy-PEI NPs,as photothermal agents,have an excellent application prospect in the field of antimicrobial photothermal therapy.
出处
《功能材料》
CAS
CSCD
北大核心
2022年第9期9127-9133,9153,共8页
Journal of Functional Materials
基金
国家自然科学基金面上项目(52073234)。
关键词
聚吡咯
光热疗法
抗菌
静电吸附
聚乙烯亚胺
polypyrrole
photothermal therapy
antibacterial
electrostatic adsorption
polyethyleneimine
