摘要
目的观察支气管哮喘发作期患儿血清骨膜蛋白(Periostin)水平与中医证型的关系并探讨其作用机制。方法选取120例哮喘发作期患儿,对比不同中医证型患儿Periostin、免疫球蛋白E(IgE)、白细胞介素-6(IL-6)、嗜酸性粒细胞、第1秒用力呼气容积(FEV1)、第1秒用力呼气量占总肺活量的比值(FEV1/FVC)、哮喘控制测试(ACT)评分差异;分析血清Periostin水平与ACT评分相关性。结果热哮型患儿血清Periostin水平显著高于风哮型、冷哮型(P<0.05),且风哮型血清Periostin水平高于冷哮型(P<0.05)。热哮型患儿嗜酸性粒细胞、IgE及IL-6水平显著高于风哮型、冷哮型(P<0.05),且风哮型嗜酸性粒细胞、IgE及IL-6水平高于冷哮型(P<0.05)。热哮型患儿FEV1、FEV1/FVC显著低于风哮型、冷哮型(P<0.05),且风哮型FEV1、FEV1/FVC低于冷哮型(P<0.05)。热哮型患儿ACT评分显著低于风哮型、冷哮型(P<0.05),且风哮型ACT评分低于冷哮型(P<0.05)。热哮型、风哮型、冷哮型患儿血清Periostin水平均与FEV1、FEV1/FVC、ACT评分呈负相关(P<0.05)。结论儿童哮喘急性发作期中医证型以热哮、风哮、冷哮为主,热哮者血清Periostin水平最高,Periostin可作为哮喘证型客观化的依据。
Objective:To evaluate the correlation analysis between serum Periostin and TCM syndrome types in children with acute attack of bronchial asthma.Methods:A total of 120 children with acute attack of bronchial asthma were selected.The Periostin,IgE,IL-6,EOS,FEV1,FEV1/FVC and ACT score were compared between different TCM syndrome types.The correlation between serum Periostin level and ACT score was analyzed.Results:The serum Periostin of heat wheezing group was more than those in wind wheezing group and cold wheezing group(P<0.05),and the serum Periostin of wind wheezing group was more than cold wheezing group(P<0.05).The EOS,IgE and IL-6 of heat wheezing group was more than those in wind wheezing group and cold wheezing group(P<0.05),and the EOS,IgE and IL-6 of wind wheezing group was more than cold wheezing group(P<0.05).The FEV1 and FEV1/FVC of heat wheezing group was less than those in wind wheezing group and cold wheezing group(P<0.05),and the FEV1 and FEV1/FVC of wind wheezing group was less than cold wheezing group(P<0.05).The ACT score of heat wheezing group was less than those in wind wheezing group and cold wheezing group(P<0.05),and the ACT score of wind wheezing group was less than cold wheezing group(P<0.05).The expression of Periostin was negative correlation with FEV1,FEV1/FVC and ACT scores in children with heat wheezing,wind wheezing and cold wheezing(P<0.05).Conclusion:The TCM syndrome types in children with acute attack of bronchial asthma is mainly heat wheezing,wind wheezing and cold wheezing.Serum Periostin is the highest in children with heat wheezing.Periostin can be used as the basis for the objectification of asthma syndrome.
作者
许文婷
王铭
黄婷
林秋玉
Xu Wenting;Wang Ming;Huang Ting;Lin Qiuyu(Hainan Women’s and Children’s Medical Center,Hainan,Haikou 571000,China)
出处
《中国中医急症》
2022年第9期1387-1389,1393,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
海南省自然科学基金青年基金项目(819QN396)
海南省医药卫生科研项目(2101360103A2001)
海南省临床医学中心建设项目资助(琼卫医函[2021]75号)。
关键词
支气管哮喘
儿童
骨膜蛋白
中医证候
肺功能
Bronchial asthma
Children
Periostin
TCM syndrome types
Pulmonary function
