摘要
维持妊娠需要母体免疫细胞与胎儿抗原之间的耐受平衡。母胎界面作为抵抗外来刺激的关键屏障,一直是探讨的热点。母胎界面除了胎盘和子宫之间相互作用,还受到构成蜕膜的母体免疫细胞的叠加调控。母胎免疫界面主要由自然杀伤细胞、巨噬细胞、T细胞和树突状细胞组成,这些细胞共同参与同种异体胎儿的耐受平衡及抗原防御作用。细胞代谢调节是细胞生物学功能的基础,为细胞不断提供着能量。妊娠过程中,为适应内外环境的变化母体代谢调节的速率及方向都随之变化。综述母胎界面免疫细胞的代谢调节,将母胎免疫界面的免疫学及代谢学联系起来,为免疫耐受提供新的见解,也为未来妊娠相关疾病的研究提供新的治疗方向。
Maintenance of pregnancy requires a tolerance balance between maternal immune cells and fetal antigens. The maternal-fetal interface, as a key barrier against external stimuli, has been a hot topic in the field of immunology. In addition to the interaction between placenta and uterus, the maternal-fetal interface is also regulated by the superposition of maternal immune cells that make up the decidua. The maternal-fetal immune interface is mainly composed of natural killer cell, macrophage, T cells and dendritic cells which are involved in the tolerance balance and antigen defense of allogeneic fetus. The regulation of cellular metabolism is the cornerstone of cellular biological function, providing a constant source of energy for cells. During the whole pregnancy, the rate and direction of metabolic regulation were accordingly changed in response to the internal and external environment changes. We discuss the metabolic regulation of immune cells at the maternal-fetal interface in this review by linking immunology and metabolism at the maternal-fetal immune interface, so as to provide new insights into immune tolerance and to offer a new therapeutic direction for future research in pregnancy-related diseases.
作者
张燕
肖卓妮(审校)
ZHANG Yan;XIAO Zhuo-ni(Reproductive Medicine Center,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《国际生殖健康／计划生育杂志》
CAS
2022年第5期404-408,共5页
Journal of International Reproductive Health/Family Planning
基金
国家自然科学基金(81471455)
湖北省卫健委-武汉大学人民医院联合基金(2020LHZ012)。
关键词
妊娠
代谢
免疫耐受
杀伤细胞
天然
巨噬细胞
T淋巴细胞
树突细胞
Pregnancy
Metabolism
Immune tolerance
Killer cells
natural
Macrophages
T-lymphocytes
Dendritic cells
