摘要
目的:分析精神科住院老年患者潜在不适当用药情况及其影响因素。方法:选取2019年6月—2020年7月我院精神科收治500例住院患者进行回顾性分析,根据《中国老年人潜在不适当用药判断标准(2017年版)》评价老年住院患者(Potentially inappropriate medication,PIM)情况,并将患者分为PIM组(471例)和对照组(29例),分析发生PIM的危险因素。结果:500例精神科住院患者中,发生PIM有470例(94.00%),其中涉及药物频率和占PIM总发生比例较高的前5种药物依次为劳拉西泮、奥氮平、艾司唑仑、喹硫平和氯硝西泮。单因素分析显示,PIM组和对照组年龄、住院天数、罹患疾病数、联合用药数比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,年龄、罹患疾病数、联合用药数是精神科住院老年患者PIM发生的独立危险因素。结论:精神科住院老年患者PIM发生率较高,且其危险因素包括患者年龄、罹患疾病数、联合用药数。应在早期对其影响因素进行有效干预,优化患者临床用药,减少PIM的发生,促进精神科住院老年患者合理用药。
Objective:To analyze the potential inappropriate medication and its influencing factors in hospitalized elderly psychiatric patients.Methods:A retrospective analysis was performed on 500 inpatients admitted to the psychiatric department of our hospital from June 2019 to July 2020.The Potentially inappropriate medication(PIM)was evaluated according to the‘Chinese elderly potential inappropriate medication judgment standard(2017 edition)’.The patients were divided into PIM group(471 cases)and control group(29 cases),and the risk factors of PIM were analyzed.Results:Of the 500 psychiatric inpatients,470(94.00%)had PIM.The top five drugs with high frequency and proportion of PIM were lorazepam,olanzapine,estazolam,quetiapine and clonazepam.Single factor analysis showed that there were significant differences in age,length of hospital stay,number of diseases and number of drug combinations between the PIM group and the control group(P<0.05).Multivariate logistic regression analysis showed that the age of patients,the number of diseases and the number of combined medications were independent risk factors for PIM in elderly hospitalized psychiatric patients.Conclusion:The incidence of PIM in hospitalized elderly psychiatric patients is high,and the risk factors include age,number of diseases and number of combined drugs.The influencing factors should be effectively intervened in the early stage to optimize the clinical medication of patients,reduce the occurrence of PIM,and promote the rational drug use of elderly hospitalized psychiatric patients.
作者
蔡荣
魏新敏
CAI Rong;WEI Xinmin(Department of Psychiatric,Guangzhou Panyu Third People's Hospital,Guangzhou 511483,Guangdong,China)
出处
《中国药物滥用防治杂志》
CAS
2022年第8期1026-1030,共5页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
精神科
老年患者
潜在不适当用药
影响因素
Department of psychiatric
Gerontal patient
Potential inappropriate medication
Influencing factor
