摘要
目的:分析还原型谷胱甘肽+复方甘草酸苷对酒精性肝硬化(AC)患者肝功能、肝纤维化的影响。方法:选取2019年2月—2020年10月河南省内黄县人民医院收治的98例AC患者作为研究对象进行前瞻性研究,采用随机数表法分组,两组患者均接受基础干预。单一组49例患者以复方甘草酸苷治疗,二联组49例患者以复方甘草酸苷+还原型谷胱甘肽治疗。比较两组疗效及治疗前后谷氨酰转肽酶(GGT)、丙氨酸氨基转移酶(ALT)、Ⅳ型胶原(Ⅳ-C)、Ⅲ型前胶原(PC-Ⅲ)、透明质酸酶(HA)水平变化、肿瘤坏死因子-α (TNF-α)、白细胞介素-6 (IL-6)水平变化、不良反应发生率。结果:两组患者总有效率比较,二联组91.84%高于单一组75.51%,差异有统计学意义(χ^(2)=4.781,P<0.05);与单一组比较,治疗后二联组GGT、ALT、Ⅳ-C、PC-Ⅲ、HA水平较低,差异有统计学意义(t=17.275、44.406、12.181、12.837、27.832,P<0.05);而治疗后二联组血清TNF-α、IL-6水平低于单一组,两组均无明显不良反应发生。结论:还原型谷胱甘肽+复方甘草酸苷对AC效果确切,能抑制机体肝纤维化,改善肝功能,进一步降低机体炎症反应,且具有较高安全性。
Objective: To analyze the effects of reduced glutathione + compound glycyrrhizin on liver function and liver fibrosis in patients with alcoholic cirrhosis(AC). Methods: 98 AC patients admitted to the hospital from February 2019 to October 2020were selected for prospective study, and divided into two groups by random number table method. All patients received basic intervention. 49 patients in the single group were treated with compound glycyrrhizin, and 49 patients in the dual group were treated with compound glycyrrhizin + reduced glutathione. The curative effect, changes in the levels of glutamyl transpeptidase(GGT), alanine aminotransferase(ALT), type IV collagen(Ⅳ-C), type Ⅲ procollagen(PC-Ⅲ), hyaluronidase(HA), the levels of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) and the incidence of adverse reactions before and after treatment were compared between the two groups of patients. Results: The total effective rate of the dual group was 91.84%, which was higher than 75.51% of the single group, and the difference was statistically significant(χ^(2)=4.781, P<0.05). Compared with the single group, the levels of GGT, ALT, Ⅳ-C, PC-Ⅲ and HA in the dual group after treatment were lower, the difference was statistically significant(t=17.275, 44.406, 12.181, 12.837, 27.832, P<0.05). After treatment, the serum levels of TNF-α and IL-6 in the combination group were lower than those in the single group, and there were no obvious adverse reactions in the two groups. Conclusion: Reduced glutathione + compound glycyrrhizin has exact effect on AC, can inhibit liver fibrosis and improve liver function. It further reduces the body’s inflammatory response and has high safety.
作者
李园园
LI Yuan-yuan(Department of General Internal Medicine,People’s Hospital of Neihuang County,Anyang,Henan,456300,China)
出处
《黑龙江医学》
2022年第17期2078-2080,共3页
Heilongjiang Medical Journal
