摘要
目的探讨穴位埋线联合柴龙逆萎汤及质子泵抑制剂对肝胃气滞型非H.pylori感染慢性非萎缩性胃炎的效果,为临床寻找更为有效的治疗方法提供参考。方法选取2016年1月至2018年12月治疗并满足研究条件的肝胃气滞型非H.pylori感染慢性非萎缩性胃炎患者200例,随机数字表法分为对照组和研究组,每组100例。对照组患者采用质子泵抑制剂奥美拉唑治疗,研究组在对照组基础上辅以穴位埋线联合柴龙逆萎汤治疗。评估患者治疗前后中医证候积分,检测患者治疗前后白介素-8(IL-8)、白介素-11(IL-11)以及胃泌素-17(G-17)水平变化情况,检测胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)以及PGⅠ/PGⅡ等水平变化情况,评估2组治疗效果,并对患者进行6个月的随访,比较2组复发情况。结果研究组总有效率为91.00%高于对照组的78.00%(P<0.05);研究组中医证候积分低于对照组(P<0.05);研究组IL-8、IL-11水平低于对照组,G-17水平高于对照组(P<0.05);研究组PGⅠ、PGⅠ/PGⅡ水平高于对照组,PGⅡ水平低于对照组(P<0.05);研究组复发率为4.40%低于对照组的14.10%(P<0.05)。结论肝胃气滞型非H.Pylory感染慢性非萎缩性胃炎中,在质子泵抑制剂治疗基础上辅以穴位埋线联合柴龙逆萎汤,有效促进患者炎性症状改善、促进胃黏膜功能,有助于提升及巩固临床治疗效果。
Objective To investigate the therapeutic effects of catgut implantation at acupoints combined with Chailongniwei decoction and proton pump inhibitors on chronic non-atrophic gastritis with non-Hp infection caused by liver and stomach qi stagnation,so as to provide reference for clinical search for more effective treatment methods.Methods Two hundred patients with patients with chronic non-atrophic gastritis and non-Hp infection caused by liver and stomach qi stagnation who were treated in our hospital from January 2016 to December 2018 were enrolled in the study,who were randomly divided into two groups.The patients in control group were treated by omeprazole(a proton pump inhibitor),however,those in research group,on the basis of control group,were treated by catgut implantation at acupoints combined with Chailongniwei decoction.The TCM syndrome scores before and after treatment,and the levels of interleukin-8(IL-8),interleukin-11(IL-11)and gastrin-17(G-17),and the levels of pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ)and PGⅠ/PGⅡwere observed and compared between the two groups.Moreover the patients were followed up for 6 months to evaluate the therapeutic effects and the recurrence rate.Results After treatment,the total effective rate in research group was 91.00%,which was significantly higher than that(78.00%)in control group(P<0.05).The TCM syndrome cores in research group were significantly lower than those in control group(P<0.05).Moreover the levels of IL-8 and IL-11 in research group were significantly lower than those in control group(P<0.05),however the levels of G-17 were significantly higher than those in control group(P<0.05).In addition the levels of PGⅠand PGⅠ/PG PGⅡin research group were significantly higher than those in control group(P<0.05),but,the PGⅡlevels were significantly lower than those in control group(P<0.05).Furthermore the recurrence rate in research group was 4.40%,which was significantly lower than that(14.10%)in control group(P<0.05).Conclusion The catgut implantation at acupoints combined with Chailongniwei decoction and proton pump inhibitors can effectively promote the improvement of inflammatory symptoms and gastric mucosal function of patients with chronic non-atrophic gastritis and non-Hp infection caused by liver and stomach qi stagnation,which is helpful for improving the clinical curative effects.
作者
李永娟
刘永香
刘倩
赵俊精
刘国通
LI Yongjuan;LIU Yongxiang;LIU Qian(Department of Digestive Diseases,Langfang People’s Hospital,Hebei,Langfang 065000,China;不详)
出处
《河北医药》
CAS
2022年第17期2599-2602,共4页
Hebei Medical Journal
基金
廊坊市科学技术研究与发展支撑计划项目(编号:2016013172)。
