摘要
为寻找高效与低毒的吡唑肟活性物质,设计、合成了9个未见文献报道的吡唑肟化合物6a~6i,并通过^(1)H NMR、^(13)C NMR及元素分析等方法表证了其目标物的结构。初步生物活性测试数据显示,在500μg/mL浓度下,目标化合物6a~6i对粘虫均有较好的杀灭效果,杀死率均为100%,与对照药啶虫丙醚的杀虫效果相当,值得进一步深入研究。
To find new pyrazole oximes with excellent bioactivities and low toxicity,nine novel pyrazole oxime derivatives were synthesized.The structures of the aimed compounds were characterized through ^(1)H NMR,^(13)C NMR and elemental analysis.Preliminary bioassay data displayed that at the concentration of 500 μg/mL,all the title compounds 6 a~6 i showed 100% insecticidal activities against Oriental armyworm,which were comparable to the commercial insecticide Pyridalyl.These compounds may be selected as lead compounds for further study.
作者
张紫婵
郑丹丹
石玉军
丁颖
李建华
严瑞健
张敏
王杨
戴红
ZHANG Zichan;ZHENG Dandan;SHI Yujun;DING Ying;LI Jianhua;YAN Ruijian;ZHANG Min;WANG Yang;DAI Hong(College of Chemistry and Chemical Engineering,Nantong University,Nantong 226019,China)
出处
《合成化学》
CAS
2022年第9期749-755,共7页
Chinese Journal of Synthetic Chemistry
基金
南通市科技计划(MS22020024)。
关键词
吡唑肟
设计合成
杀虫活性
pyrazole oxime
design and synthesis
insecticidal activity
