摘要
目的探讨益生菌联合维生素D辅助治疗对妊娠期糖尿病(GDM)患者胰岛素抵抗、血糖波动及妊娠结局的影响。方法选取2018年2月至2021年2月收治的80例GDM患者为研究对象,根据随机数字表法将其分为对照组和观察组,各40例。对照组行常规治疗加维生素D辅助治疗,观察组在对照组基础上联合益生菌治疗。比较两组的治疗效果。结果治疗后,观察组的糖化血红蛋白(HbA1c)及空腹血糖(FPG)、餐后2 h血糖(2 h PG)水平低于对照组,空腹胰岛素(FINS)水平高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的胰岛β细胞功能指数(HOMA-β)、胰岛素敏感指数(ISI)高于对照组,胰岛素抵抗指数(HOMA-IR)低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的日间血糖平均绝对值(MODD)、日内平均血糖波动幅度(MAGE)低于对照组,差异具有统计学意义(P<0.05)。观察组的不良妊娠结局总发生率低于对照组,差异具有统计学意义(P<0.05)。结论益生菌联合维生素D辅助治疗GDM可降低胰岛素抵抗,控制血糖波动,改善妊娠结局,值得临床推广和应用。
Objective To explore the effects of probiotics combined with vitamin D adjuvant therapy on insulin resistance,plasma glucose fluctuation and pregnancy outcome in patients with gestational diabetes mellitus(GDM).Methods A total of 80 patients with GDM admitted from February 2018 to February 2021 were selected as the research objects.According to the random number table method,the patients were divided into control group and observation group,with 40 cases in each group.The control group was treated with routine therapy plus vitamin D adjuvant therapy,and the observation group was treated with probiotics on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the levels of glycated hemoglobin(HbA1c),fasting plasma glucose(FPG)and 2 hour postprandial plasam glucose(2 h PG)in the observation group were lower than those in the control group,the level of fasting insulin(FINS)was higher than that in the control group,and the differences were statistically significant(P<0.05).After treatment,the homeostasis model assessment of β cell function index(HOMA-β),insulin sensitivity index(ISI)in the observation group were higher than those in the control group,the homeostasis model assessment of insulin resistance(HOMA-IR)was lower than that in control group,and the differences were statistically significant(P<0.05).After treatment,the levels of mean of daily differences(MODD)and mean amplitude of glycemic excuisions(MAGE)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Probiotics combined with vitamin D adjuvant therapy of GDM mellitus can reduce insulin resistance,control plasma glucose fluctuation and improve pregnancy outcomes,which is worthy of clinical popularization and application.
作者
黄喜英
孙利
赵晓利
HUANG Xiying;SUN Li;ZHAO Xiaoli(Xi'an No.1 Hospital,Xi'an 710002,China)
出处
《临床医学研究与实践》
2022年第28期37-40,共4页
Clinical Research and Practice
基金
陕西省科技计划项目(No.2013SFZ-06)。
关键词
益生菌
维生素D
妊娠期糖尿病
胰岛素抵抗
血糖波动
妊娠结局
probiotics
vitamin D
gestational diabetes mellitus
insulin resistance
plasma glucose fluctuation
pregnancy outcome
