摘要
Non-coding RNAs are speculated to exert important regulatory functions at the level of gene expression,oncogenesis,and many other pathologies.Hepatitis B virus(HBV)infection is a leading cause of hepatocellular carcinoma(HCC),and some studies have shown that the expression of non-coding RNAs has an assignable effect on the development of HBV-induced HCC.In this context,the functions and molecular mechanisms of the HBVinduced non-coding RNA expression in the development of hepatoma have attracted increasing attention.This review covers the progress in the exploration of the relationship between HBV-induced hepatoma and non-coding RNA expression,cataloging the recent reports about the roles of non-coding RNAs in HBV-induced hepatoma into five classes,including(1)modulation of metabolism in hepatic cancer,(2)aggravation of inflammation and hepatic fibrosis,(3)alteration of the tumor immune microenvironment,(4)non-coding RNA N6-methyladenosine modification,and a seemingly opposite process,(5)the suppression of the progression of HBV-related HCC.All evidence supports non-coding RNAs as promising novel targets for the early diagnosis and treatments for HCC.
基金
This work was supported by the Key Research&Development Plan of Zhejiang Province(2019C04005)
the National Key Research and Development Program of China(2018YFC2000500).
