摘要
目的探究降钙素原对急诊脓毒症患者早期诊断的临床价值,为急诊脓毒症早期诊断提供依据。方法选取51例急诊脓毒症患者作为观察组,根据病情严重程度分为A组(轻度脓毒症,11例)、B组(重度脓毒症,19例)、C组(脓毒性休克,21例);另选择同期45例体检健康者作为对照组。观察组和对照组均采用酶联免疫发光分析法进行降钙素原检测。比较观察组与对照组降钙素原水平,A组、B组、C组降钙素原水平及预后情况[急性生理与慢性健康系统Ⅱ(APACHEⅡ)评分、序贯器官衰竭估计(SOFA)评分]。结果观察组降钙素原为(2.80±0.81)μg/L,高于对照组的(0.15±0.07)μg/L,差异具有统计学意义(P<0.05)。A组降钙素原为(1.21±0.33)μg/L,B组为(2.60±1.47)μg/L,C组为(3.81±1.43)μg/L;A组降钙素原水平低于B组、C组,B组低于C组,差异具有统计学意义(P<0.05)。A组APACHEⅡ评分、SOFA评分分别为(15.47±3.21)、(3.49±2.21)分,B组分别为(19.03±5.21)、(5.53±2.37)分,C组分别为(28.13±6.03)、(10.89±3.49)分;A组APACHEⅡ评分、SOFA评分低于B组、C组,B组低于C组,差异具有统计学意义(P<0.05)。结论动态监测降钙素原水平,可提高脓毒症早期诊断效果,评估病情严重程度及预后情况,以指导临床治疗,改善患者临床结局。
Objective To investigate the clinical value of procalcitonin in early diagnosis of emergency patients with sepsis,so as to provide a basis for the early diagnosis of emergency sepsis.Methods 51 emergency patients with sepsis were selected as observation group and were divided into group A(mild sepsis,11 cases),group B(severe sepsis,19 cases)and group C(septic shock,21 cases)according to the severity of the disease;another 45 healthy subjects with physical examination during the same period were selected as the control group.Both the observation group and the control group were detected by enzyme-linked immunoluminescence assay for procalcitonin.Comparison was made on levels of procalcitonin between the observation group and the control group,as well as the levels of procalcitonin and the prognosis[Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score,Sequential Organ Failure Assessment(SOFA)score]in group A,group B,and group C.Results The procalcitonin in the observation group was(2.80±0.81)μg/L,which was higher than(0.15±0.07)μg/L in the control group,and the difference was statistically significant(P<0.05).The procalcitonin in group A was(1.21±0.33)μg/L,that in group B was(2.60±1.47)μg/L,and that in group C was(3.81±1.43)μg/L.The procalcitonin in group A was lower than that in group B and group C,group B was lower than group C,and the differences were statistically significant(P<0.05).The APACHE Ⅱ score and SOFA score of group A were(15.47±3.21)and(3.49±2.21)points,those of group B were(19.03±5.21)and(5.53±2.37)points,and those of group C were(28.13±6.03)and(10.89±3.49)points.The APACHE Ⅱ score and SOFA score of group A were lower than those of group B and group C,and group B was lower than that of group C,and the differences were statistically significant(P<0.05).Conclusion Dynamic monitoring of procalcitonin level can improve the effect of early diagnosis of sepsis,evaluate the severity of the disease and the development of prognosis,guide clinical treatment and improve the clinical outcome of patients.
作者
刘红丹
LIU Hong-dan(Emergency Department,Shenyang Tenth People's Hospital,Shenyang 110044,China)
出处
《中国现代药物应用》
2022年第17期80-82,共3页
Chinese Journal of Modern Drug Application
关键词
脓毒症
降钙素原
急诊科
早期诊断
价值
Sepsis
Procalcitonin
Emergency department
Early diagnosis
Value
