摘要
目的探究碘摄入量与BRAF V600E基因突变以及甲状腺乳头状癌(papillary thyroid carcinoma,PTC)发生发展的相关性,为合理碘摄入量提供科学依据。方法选取2016年1月至2019年1月间,邢台医学高等专科学校第一附属医院内分泌科收治的邢台地区共124例PTC患者为观察对象,设为观察组,留取住院前尿液10 m L,监测尿碘水平并计算其中位数,并行BRAF V600E突变基因检测,同时选取同期同地区的120例甲状腺正常人群设为对照组,以相同办法进行对比研究。结果观察组PTC患者中位尿碘值(median urinary iodin,MUI)水平为343μg/L,明显高于对照组甲状腺功能正常者192μg/L(P<0.05);观察组124例PTC患者中发生BRAF V600E基因突变80例(64.5%),明显高于对照组0%(P<0.05);突变基因型在尿碘值分组间比较,碘缺乏组、碘足量组、碘超足量组及碘过量组中BRAF V600E基因突变率分别为16.7%、50.0%、64.9%及74.6%,BRAF V600E基因突变率伴随着尿碘值增加而增加,组间比较差异显著(P=0.004)。结论PTC组织中存在高机率BRAF V600E基因突变,同时高碘摄入作为BRAF V600E基因突变的重要危险因素,与PTC发病率存在一定的相关性。
Objective To explore the correlation between iodine intake and BRAF V600E gene mutation and the development of thyroid papillary carcinoma(PTC),to provide a scientific basis for reasonable iodine intake.Methods From January 2016 to January 2019,a total of 124 patients with PTC admitted to the Department of Endocrinology,The First Affiliated Hospital of Xingtai Medical College were selected as the observation group.Meanwhile,the BRAF V600E mutation gene was detected.At the same time,120 normal thyroid function subjects in the same area were selected as the control group,and a comparative study was conducted in the same way.Results The urinary iodine value(MUI)level of the observation group PTC was(342.8±27.5)μg/L,significantly higher than that in the control group(187.9±17.7)μg/L(P<0.05).Among the 124 PTC patients,80 cases of BRAF V600E gene mutation were found(64.5%),significantly higher than that in the control group(n=0)(P<0.05).Mutation genotype in urine iodine value comparison between groups,iodine deficiency group,iodine enough,iodine adequate,and iodine excess group of BRAF V600E mutation rate were 16.7%,50.0%,64.9%,and 16.7%respectively,BRAF V600E mutation rate associated with urinary iodine value increases,the more significant difference between groups(P=0.004).Conclusions There was a high probability of genetic mutation of BRAF V600E in PTC patients,while high iodine intake was a significant risk factor for BRAF V600E gene mutation,and there might be a correlation with PTC incidence.
作者
李小妹
王利利
李想
杜丽艳
宋爱林
LI Xiao-mei;WANG Li-li;LI Xiang;DU Li-yan;SONG Ai-lin(Department of Head and Neck Mammary Gland,The First Affiliated Hospital of Xingtai Medical College,Hebei Xingtai 054001,China;Department of Ultrasound,The First Affiliated Hospital of Xingtai Medical College,Hebei Xingtai 054001,China;Department of Surgical Anesthesia,The First Affiliated Hospital of Xingtai Medical College,Hebei Xingtai 054001,China)
出处
《循证医学》
2022年第3期159-162,共4页
The Journal of Evidence-Based Medicine
基金
河北省邢台市科技局科技计划项目(2019ZC326)。
