摘要
癌症是全世界死亡的主要原因之一,不断演进的抗癌药物使癌症患者的生存期明显延长。心血管疾病逐步取代癌症本身成为癌症患者致死和致残的主要原因,高血压是其中最常见的心血管疾病之一,所以监测及管理肿瘤患者的血压对降低化疗引起的心脏毒性风险和降低长期心血管疾病的风险至关重要。本文主要回顾与高血压发生相关的常见抗肿瘤药物,包括血管内皮生长因子抑制剂、小分子酪氨酸激酶抑制剂、蛋白酶体抑制剂、烷基化剂和免疫抑制剂等相关高血压的流行病学、潜在机制及针对性的管理建议,并讨论癌症患者应用血管内皮生长因子信号通路抑制剂相关血压的评估和管理策略。
Cancer is one of the leading causes of death worldwide,and the evolution of anti-cancer drugs has significantly prolonged the life expectancy of cancer patients.Cardiovascular diseases have gradually replaced cancer as the leading cause of morbidity and mortality in cancer patients.Among these cancer patients,hypertension is one of the most common cardiovascular diseases.Therefore,monitoring and managing blood pressure in cancer patients is crucial to reducing the risk of cardiotoxicity caused by chemotherapy and the risk of cardiovascular diseases.In this review,we reviewed common antitumor drugs related to hypertension,including vascular endothelial growth factor(VEGF)inhibitors,small molecule tyrosine kinase inhibitors,protease inhibitors,alkylating agents,and immunosuppressants.We also discussed epidemiology,underlying mechanisms,and corresponding management advice of these antitumor drugs.Finally,we discussed the blood pressure assessment and management strategy for cancer patients using VEGF pathway inhibitors.
作者
夏云龙
刘飞
XIA Yunlong;LIU Fei(Department of Cardiology,The First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning,116011,China)
出处
《临床心血管病杂志》
CAS
北大核心
2022年第8期609-613,共5页
Journal of Clinical Cardiology
关键词
高血压
肿瘤心脏病
心脏毒性
hypertension
cardio-oncology
cardiotoxicity
