摘要
背景:跟腱是运动中较为常见的损伤部位,尤其在过量或不当运动中更易受累,且损伤后难以恢复。寻找安全、有效、快速的修复方法,一直是跟腱损伤临床治疗的努力方向,但是效果并不理想。近年来间充质干细胞因其强大的修复潜能被尝试用于多种疾病的治疗,也有部分研究将间充质干细胞应用于跟腱损伤的修复,具有良好的效果。目的:总结了骨髓、脂肪及肌腱等多种组织来源间充质干细胞在跟腱损伤中的应用,探讨间充质干细胞治疗跟腱损伤的可行性及优势,为治疗跟腱损伤提供新思路。方法:通过检索CNKI数据库、万方数据库、百度学术数据库、Web of Science数据库、PubMed数据库、Google学术数据库收录的文献,英文检索词为“achilles tendon,achilles tendon injury,achilles tendon rupture,stem cells,mesenchymal stem cells,MSCs,biological materials,tissue engineering”,中文检索词为“跟腱,跟腱损伤,跟腱断裂,干细胞,间充质干细胞,生物材料,组织工程”。对筛选的文献进行整理归纳,排除不符合纳入标准的文献,最终选择101篇文献进行综述。结果与结论:不同组织来源的间充质干细胞独立应用或者联合生物材料应用,均有利于跟腱的损伤修复,但是其中涉及的具体机制还不是很清楚,可能包括间充质干细胞向腱细胞分化、调节生长因子释放及肌腱相关基因的表达等。寻找最适合跟腱损伤治疗的种子细胞和生物材料是跟腱组织工程修复的关键。
BACKGROUND:The Achilles tendon is a common site of injury in sports,especially in excessive or improper sports,which is more likely to be affected and difficult to recover after injury.To find a safe,effective,and rapid repair method is always the direction of clinical treatment of Achilles tendon injury,but the effect is not ideal.In recent years,due to the strong repair potential,mesenchymal stem cells have been tried to be used in the treatment of a variety of diseases,and some studies have applied mesenchymal stem cells to repair Achilles tendon injury,with good results.OBJECTIVE:To review the application of mesenchymal stem cells derived from bone marrow,adipose tissue,and tendon in the treatment of Achilles tendon injury,and explore the feasibility and advantages of mesenchymal stem cells in the treatment of Achilles tendon injury,providing a new idea for the treatment of Achilles tendon injury.METHODS:The articles included in CNKI database,Wanfang database,Baidu Academic Database,Web of Science database,PubMed database and Google Academic Database were searched by computer.The Chinese and English search terms were“Achilles tendon,Achilles tendon injury,Achilles tendon rupture,stem cells,mesenchymal stem cells,MSCs,biological materials,tissue engineering”.The screened articles were sorted out and summarized,and those that did not meet the inclusion criteria were excluded.Finally,101 articles were selected for review.RESULTS AND CONCLUSION:The application of mesenchymal stem cells from different tissues independently or in combination with biomaterials is beneficial for tendon injury repair,but the specific mechanisms involved are not clear,which may include the differentiation of mesenchymal stem cells into tendon cells,regulation of growth factor release and tendon related gene expression.Finding the most suitable seed cells and biomaterials for the treatment of Achilles tendon injury is the key to tissue engineering repair of Achilles tendon.
作者
李炜
蔺美娜
卢永平
隋钰
姜淼
Li Wei;Lin Meina;Lu Yongping;Sui Yu;Jiang Miao(Shenyang Sport University,Shenyang 110115,Liaoning Province,China;NHC Key Laboratory of Reproductive Health and Medical Genetics(China Medical University)&Liaoning Key Laboratory of Reproductive Health,Liaoning Research Institute of Family Planning,Department of Eugenics and Genetics,Reproductive Hospital Affiliated to China Medical University,Shenyang 110031,Liaoning Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2023年第15期2404-2411,共8页
Chinese Journal of Tissue Engineering Research
基金
辽宁省重点研发计划(2017020199-201)
项目负责人:姜淼
关键词
跟腱损伤
间充质干细胞
生物衍生材料
聚合物材料
综述
Achilles tendon injury
mesenchymal stem cell
biological derived material
polymer material
review
