摘要
目的 探讨冷圈套内镜下黏膜切除术治疗结直肠息肉的效果及对应激反应、水通道蛋白表达的影响。方法 选取2019年1月至2021年3月我院收治的86例结直肠息肉患者作为研究对象,根据手术方法将其分为对照组(43例,热圈套内镜下黏膜切除术)与观察组(43例,冷圈套内镜下黏膜切除术)。比较两组的治疗效果。结果 术后即刻,两组的C反应蛋白(CRP)、肾上腺素(E)、皮质醇(Cor)水平均升高,而观察组的CRP、E、Cor水平低于对照组(P<0.05)。术后3d,两组的水通道蛋白3(AQP3)、水通道蛋白4(AQP4)表达水平均升高,且观察组高于对照组(P<0.05)。两组的完整切除率无明显差异(P>0.05)。观察组的延迟性出血率、延迟性穿孔率低于对照组(P<0.05)。结论 采用冷圈套内镜下黏膜切除术治疗结直肠息肉可获得与热圈套内镜下黏膜切除术相媲美的完整切除率,但冷圈套内镜下黏膜切除术对患者造成的应激反应更小,可作为首选术式。
Objective To investigate the effect of cold snare endoscopic mucosal resection on colorectal polyps and its influence on stress response and aquaporin expression.Methods A total of 86 patients with colorectal polyps admitted in our hospital from January 2019 to March 2021 were selected as the research objects,and the patients were divided into control group(43 cases,hot snare endoscopic mucosal resection) and observation group(43 cases,cold snare endoscopic mucosal resection) according to the surgical methods.The therapeutic effects of the two groups were compared.Results Immediately after operation,the levels of C-reactive protein(CRP),epinephrine(E) and cortisol(Cor) in the two groups increased,while the levels of CRP,E and Cor in the observation group were lower than those in the control group(P0.05).The rates of delayed hemorrhage and delayed perforation in the observation group were lower than those in the control group(P<0.05).Conclusion Cold snare endoscopic mucosal resection in the treatment of colorectal polyps can obtain a complete resection rate comparable to the hot snare endoscopic mucosal resection.But cold snare endoscopic mucosal resection for patients has less stress response and can be used as the preferred surgical procedure.
作者
樊和明
李琳芳
FAN Heming;LI Linfang(Digestive Endoscopy Department,Xinxiang First People's Hospital,Xinxiang 453000,China)
出处
《临床医学研究与实践》
2022年第29期79-81,共3页
Clinical Research and Practice
