摘要
目的比较同时期采用单克隆抗体免疫诱导和多克隆抗体免疫诱导治疗受者肾移植术后尿液及血液BK病毒感染的情况。方法回顾性收集2017年1月—2019年7月于山西省第二人民医院行肾移植术共298例患者术后尿液、血液BK病毒DNA检测结果。根据免疫诱导治疗方案的不同分为单克隆抗体免疫诱导治疗组85例和多克隆抗体免疫诱导治疗组213例,比较两组BK病毒感染情况,探讨不同免疫诱导治疗方案对肾移植受者BK病毒感染的影响。结果所有患者尿BK病毒阳性率为50.00%(149/298),血BK病毒阳性率为3.69%(11/298),肾移植术后尿BK病毒阳性率明显高于血BK病毒阳性率(P<0.01);单克隆抗体组尿BK病毒阳性率为50.59%(43/85),多克隆抗体组尿BK病毒阳性率为49.77%(106/213),差异无统计学意义(χ^(2)=0.165,P>0.05);单克隆抗体组血BK病毒阳性率为2.35%(2/85),多克隆抗体组血BK病毒阳性率为4.22%(9/213),差异无统计学意义(χ^(2)=0.188,P>0.05)。结论单克隆抗体与多克隆抗体免疫诱导治疗组肾移植术后BK病毒的感染无明显差异,但两组BK病毒的感染率非常高,应加强肾移植术后BK病毒的监测,及时调整免疫抑制方案。
Objective To compare the BK virus infection in urine and blood of kidney transplantation recipients under the therapy of monoclonal antibody immune induction or polyclonal antibody immune induction during the same period.Methods The urine and blood BK virus DNA test results of a total of 298 patients who underwent kidney transplantation in our hospital from January 2017 to July 2019 were retrospectively collected.According to the different immune induction treatment regimens,the recipients were divided into two groups:monoclonal antibody group with 85 cases,and polyclonal antibody group with 214 cases.The BK virus infection results in both groups were compared,the impact of the different immunization induction therapy on the BK virus infection in kidney transplant recipients was explored.Results The results of all the patients show that the positive rate of urine BK virus was 50.00%(149/298),the positive rate of blood BK virus was 3.69%(11/298).After the kidney transplantation,the positive rate of urine BK virus was significantly higher than that of blood BK virus(P<0.01).The positive rate of urine BK virus in the monoclonal antibody group was 50.59%(43/85),and the positive rate of urine BK virus in the polyclonal antibody group was 49.77%(106/213),the difference was not statistically significant(χ^(2)=0.165,P>0.05).The positive rate of BK virus in the blood of the monoclonal antibody group was 2.35%(2/85),and the positive rate of BK virus in the blood of the polyclonal antibody group was 4.22%(9/213),the difference was not statistically significant(χ^(2)=0.188,P>0.05).Conclusion For the BK virus infection after the kidney transplantation,there is no significant difference between monoclonal antibody immune induction therapy group and polyclonal antibody immune induction therapy group.While the infection rate of BK virus in both groups is very high.After the kidney transplantation,strengthening the monitoring of BK virus and adjusting the immunosuppressive regimen in time are very important.
作者
王卫
周华
贾志缃
陈好雨
武小桐
Wang Wei;Zhou Hua;Jia Zhizang;Chen Haoyu;Wu Xiaotong(The Second People's Hospital of Shanxi Province,Kidney Transplant and Blood Purification Center,Taiyuan 030000,Shanxi,China)
出处
《实用器官移植电子杂志》
2022年第5期418-422,共5页
Practical Journal of Organ Transplantation(Electronic Version)
基金
山西省卫生健康委科研课题计划项目(2020014)。
关键词
BK病毒
肾移植
免疫诱导
BK virus
Kidney transplantation
Immune induction
