摘要
运用MCI Gel、Sephadex LH-20、ODS和硅胶等柱色谱,结合半制备液相、TLC等分离方法,从思茅松松脂的95%乙醇部位分离纯化得到7个化合物。运用现代波谱学方法(1D、2D NMR、UV、IR、MS等)对所分离得到的化合物进行结构鉴定,并运用计算ECD的方法确定了新化合物的绝对构型。其中,化合物1为新化合物,化合物2、5~7为首次从思茅松中分离得到。
One undescribed diterpenoid acid and six compounds were isolated from the 95%ethanol fraction of Pinus kesiya var.langbianensis(A.Chev.)Gaussen ex Bui resin by using various chromatographic methods,including MCI Gel,Sephadex LH-20,ODS,silica gel and semi-preparative HPLC.The planar structures were identified by spectroscopy methods(1D,2D NMR,UV,IR,MS,etc.),and the absolute configuration of the new compound was determined by ECD calculation.Compound 1 is a new compound,and compounds 2,5-7 were isolated from Pinus kesiya var.langbianensis(A.Chev.)Gaussen ex Bui for the first time.
作者
刘煜飞
王彦志
宋志敏
乔霖清
彭锐
冯卫生
程永现
LIU Yu-fei;WANG Yan-zhi;SONG Zhi-min;QIAO Lin-qing;PENG Rui;FENG Wei-sheng;CHENG Yong-xian(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province&Education Ministry of P.R.China,Zhengzhou 450046,China;School of Pharmaceutical Sciences,Institute for Inheritance-Based Innovation of Chinese Medicine,Shenzhen University,Shenzhen 518060,China)
出处
《药学学报》
CAS
CSCD
北大核心
2022年第9期2786-2790,共5页
Acta Pharmaceutica Sinica
基金
国家重点研发计划(2017YFA0503900)
国家杰出青年科学基金资助项目(81525026).
关键词
思茅松
松脂
二萜酸
提取分离
化学成分
Pinus kesiya var.langbianensis(A.Chev.)Gaussen ex Bui
rosin
diterpenoid acid
extraction and separation
chemical composition
