摘要
目的探讨胰岛素样生长因子1(insulin-like growth factor 1,IGF-1)单核苷酸多态性与非小细胞肺癌(non-small cell lung cancer,NSCLC)患者疼痛和生活质量的关系。方法回顾性分析2019年9月至2021年12月宁波大学附属人民医院收治的398例NSCLC患者,采用TaqMan探针法对研究对象的IGF-1基因位点(rs6214、rs35767、rs5742612)进行基因分型,采用数字评分法(numerical rating scales,NRS)和8条目健康调查简表(short-form health survey-8,SF-8)评价患者的疼痛和生活质量,采用单因素和多因素Logistic回归分析评价疼痛NRS得分和SF-8得分的影响因素。结果未发现rs6214与疼痛和生活质量的关系;在NSCLC患者中,IGF-1 rs5742612 AA、AG、GG基因型携带者的术后3d疼痛NRS评分分别为(5.49±1.76)、(5.53±1.84)、(4.38±1.92)分,术后7d疼痛NRS评分分别为(4.86±1.82)、(4.88±1.95)、(3.91±2.04)分,差异均有统计学意义(P=0.002、0.019)。生活质量评分方面,rs35767GG、GA、AA基因型携带者之间的机体功能得分[(21.23±24.71)vs(18.03±20.53)vs(28.06±23.74)]与躯体角色得分[(60.09±16.28)vs(62.70±16.55)vs(68.37±19.62)]差异均有统计学意义(P=0.022、0.010);rs5742612AA、AG、GG基因型携带者的生命力得分分别为(41.22±18.25)、(41.51±19.86)、(51.47±22.14)分,差异有统计学意义(P=0.014)。多因素Logistic回归分析显示,rs5742612基因多态性为术后3、7d疼痛NRS评分的独立影响因素(P=0.008、0.010),rs35767基因多态性为躯体角色得分的独立影响因素(P<0.001)。结论IGF-1基因多态性与NSCLC患者的疼痛和生活质量有关,可为更好地实现个体化疼痛和生活质量提供有价值的信息。
Objective To investigate the association of insulin-like growth factor 1(IGF-1)single nucleotide polymorphism with pain and quality of life in patients with non-small cell lung cancer(NSCLC).Methods Three hundred and ninety-eight patients with NSCLC who were treated in the Affiliated People's Hospital of Ningbo University from September 2019 to December 2021 were retrospectively selected as the research subjects.The IGF-1 loci(rs6214,rs35767,rs5742612)were genotyped by the TaqMan probe method,and the pain and life of the patients were evaluated by the Numerical Rating Scales(NRS)and Short-Form Health Survey-8(SF-8).Univariate and multivariate logistic regression analysis was used to evaluate the influencing factors of pain NRS and SF-8 score.Results No relationship between rs6214 and pain and quality of life was found;In NSCLC patients,the postoperative 3d and 7d pain NRS in IGF-1 rs5742612 AA,AG,GG genotype carriers were(5.49±1.76),(5.53±1.84),(4.38±1.92),(4.86±1.82),(4.88±1.95),(3.91±2.04),the differences were statistically significant(P=0.002,0.019).In the quality of life score,the body function scores and body role scores between rs35767GG,GA,and AA genotype carriers were(21.23±24.71)vs(18.03±20.53)vs(28.06±23.74)and(60.09±16.28)vs(62.70±16.55)vs(68.37±19.62),respectively,the differences were statistically significant(P=0.022,0.010);the role-physical scores between rs5742612AA,AG,GG genotype carriers were(41.22±18.25),(41.51±19.86),(51.47±22.14),the differences were statistically significant(P=0.014).The multivariate logistic regression analysis showed that rs5742612 gene polymorphism was an independent influencing factor of postoperative 3d and 7d pain NRS(P=0.008,0.010),and rs35767 gene polymorphism was an independent influencing factor of role-physical score(P<0.001).Conclusion IGF-1 gene polymorphisms are associated with pain and quality of life in patients with NSCLC,which can provide valuable information for better individualized pain and quality of life services.
作者
郑伟
徐涛
彭卫东
吕佳佩
ZHENG Wei;XU Tao;PENG Weidong;LYU Jiapei(Department of Respiratory and Critical Care Medicine,the Affiliated People's Hospital of Ningbo University,Zhejiang,Ningbo 315000,China;Department of Geriatrics,the Affiliated People's Hospital of Ningbo University,Zhejiang,Ningbo 315000,China)
出处
《中国现代医生》
2022年第27期60-65,共6页
China Modern Doctor
基金
白求恩·医学科学研究基金资助项目(B19313FN)。
关键词
胰岛素样生长因子1
单核苷酸多态性
非小细胞肺癌
疼痛
生活质量
Insulin-like growth factor 1
Single nucleotide polymorphism
Non-small cell lung cancer
Pain
Quality of life
