摘要
目的观察甘氨双唑钠对老年局部晚期喉癌患者放疗的增敏作用。方法选取2016年6月至2018年6月湖州市第一人民医院收治的老年局部晚期喉癌患者150例。其中75例患者采用常规放疗,为对照组;另75例患者采用甘氨双唑钠联合放疗,为观察组。比较两组患者治疗效果、治疗缓解和疾病进展的放射剂量、不良反应以及治疗后1年、3年生存率。结果观察组患者治疗总有效率、疾病控制率均高于对照组(96.00%比82.67%、62.67%比41.33%,均P<0.05)。两组患者治疗缓解和疾病进展的放射剂量比较差异均无统计学意义(均P>0.05)。两组患者放疗不良反应头痛、厌食、骨髓抑制、皮肤红斑、黏膜水肿发生率比较差异均无统计学意义(均P>0.05)。生存分析显示,观察组患者中位生存时间为35.39个月,对照组中位生存时间为32.43个月。观察组患者与对照组患者1年生存率比较差异无统计学意义(97.33%比96.00%,P>0.05),观察组患者3年生存率高于对照组(92.00%比80.00%,P<0.05)。结论老年局部晚期喉癌患者应用甘氨双唑钠联合放疗效果较好,可增强放疗的敏感性,提高患者的生存率,并且不会增加放疗的不良反应。
Objective To investigate the sensitizing effect of glyburide sodium on radiotherapy in elderly patients with locally advanced laryngeal cancer.Methods A total of 150 elderly patients with locally advanced laryngeal cancer admitted to Huzhou First People’s Hospital from June 2016 to June 2018 were enrolled.Among them,75 patients were treated with conventional radiotherapy(control group)and 75 patients were given glycidazole sodium while treated with radiotherapy(study group).The treatment effect,radiation dose for treatment remission and disease progression,adverse effects and 1-year,3-year survival rate were compared between the two groups.Results The total effective rate of treatment and disease control rate of patients in study group were higher than those in the control group(96.00%vs.82.67%,62.67%vs.41.33%,P<0.05).There was no statistically significant difference between the two groups in radiation dose for treatment remission and disease progression(all P>0.05).The incidence of adverse effects of radiotherapy including headache,anorexia,bone marrow suppression,skin erythema and mucosal oedema was not statistically significant between the two groups(all P>0.05).The median survival time in study group and control group was 35.39 months and 32.43 months,respectively.There was no statistically significant difference between the 1-year survival rate between two groups(97.33%vs.96.00%,P>0.05),while the 3-year survival rate of patients in study group was higher than that in the control group(92.00%vs.80.00%,P<0.05).Conclusion Glycidazole sodium combined with radiotherapy can enhance the sensitivity of radiotherapy and improve the survival rate of patients without increase of adverse reactions for elderly patients with locally advanced laryngeal cancer.
作者
李满群
陈静宜
徐珏
LI Manqun;CHEN Jingyi;XU Yu(不详;Department of Otolaryngology,Huzhou First People's Hospital,Huzhou 313000,China)
出处
《浙江医学》
CAS
2022年第18期1947-1950,1955,共5页
Zhejiang Medical Journal
基金
浙江省医药卫生科技计划项目(2018KY772)。
关键词
喉癌
放射治疗
甘氨双唑钠
增敏作用
Laryngeal cancer
Radiation therapy
Glyburide sodium
Sensitisation
