摘要
目的:观察血清成纤维细胞生长因子19(FGF19)水平与老年2型糖尿病视网膜病变患者的相关性。方法:选取2018年6月至2020年6月该院收治的70例老年2型糖尿病患者进行前瞻性研究,根据是否伴有视网膜病变分为糖尿病视网膜病变(DR)组(n=30)与单纯糖尿病(DM)组(n=40),同时收集同期该院30名健康体检者(行OGTT检查排除糖尿病)作为对照组。比较三组血清FGF19水平、血糖指标[空腹血糖(FBG)、血清胰岛素(FINS)、糖化血红蛋白(HbA1c)]水平、血脂指标[总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)]水平和C反应蛋白(CPR)水平,采用Pearson相关性分析血清FGF19水平与血糖、血脂、CPR水平的相关性,采用受试者工作特征曲线(ROC)分析血清FGF19水平与DR的相关性。结果:DR组FGF19水平低于DM组和对照组,DM组低于对照组,差异有统计学意义(P<0.05);DR组、DM组FBG水平均高于对照组,差异有统计学意义(P<0.05);但DR组与DM组FBG水平比较,差异无统计学意义(P>0.05);DR组FINS、HbA1c、TC、TG、LDL、CRP水平均高于DM组和对照组,DM组高于对照组,差异有统计学意义(P<0.05);DR组HDL水平低于DM组和对照组,DM组低于对照组,差异有统计学意义(P<0.05);DR患者FGF19水平与TC、CRP水平呈负相关(r<0,P<0.05),与FBG、FINS、HbA1c、TG、HDL、LDL水平无相关性(P>0.05);血清FGF19水平预测DR发病的曲线下面积为0.874,具有一定的预测价值。结论:DR患者血清FGF19水平下降,且与TC、CRP水平呈负相关。
Objective:To observe correlation between serum fibroblast growth factor(FGF19)level and type 2 diabetic retinopathy in elderly patients.Methods:A prospective study was conducted on 70 elderly patients with type 2 diabetes who were admitted to this hospital from June 2018 to June 2020.They were divided into diabetic retinopathy(DR)group(n=30)and simple diabetes(DM)group(n=40).At the same time,30 healthy subjects in this hospital(with OGTT examination to exclude diabetes)were collected as control group during the same period.The serum FGF19 level,the blood glucose indicator levels[fasting blood glucose(FBG),serum insulin(FINS),glycated hemoglobin(HbA1c)],the blood lipid indicator levels[total cholesterol(TC),triglyceride(TG),high-density lipoprotein(HDL),low-density lipoprotein(LDL)],and the C-reactive protein(CPR)level were compared among the three groups.Pearson correlation was used to analyze the correlations among the serum FGF19 level and the blood glucose,blood lipids and CPR levels.Receiver operating characteristic(ROC)was drawn to analyze the correlation between the serum FGF19 level and DR.Results:The level of FGF19 in the DR group was lower than those in the DM group and the control group,that of the DM group was lower than that of the control group,and the differences were statistically significant(P<0.05).The levels of FBG in the DR group and the DM group were higher than those in the control group,and the differences were statistically significant(P<0.05);however,there was no significant difference between the DR group and the DM group(P>0.05).The levels of FINS,HbA1c,TC,TG,LDL,and CRP in the DR group were higher than those in the DM group and the control group,those of the DM group were higher than those of the control group,and the differences were statistically significant(P<0.05).The HDL level of the DR group was lower than those of the DM group and the control group,that of the DM group was lower than that of the control group,and the differences were statistically significant(P<0.05).The level of FGF19 in the DR patients was negatively correlated with the levels of TC and CRP(r<0,P<0.05);and it was not correlated with the levels of FBG,FINS,HbA1c,TG,HDL and LDL(P>0.05).The AUC area of the serum FGF19 level for predicting the onset of DR was 0.874,which had a certain predictive value.Conclusions:The serum FGF19 level in DR patients decreases,and is negatively correlated with the TC and CRP levels.
作者
冯海珍
FENG Haizhen(Department of Laboratory Medicine of Sui County Hospital of Traditional Chinese Medicine,Shangqiu 476900 Henan,China)
出处
《中国民康医学》
2022年第18期116-119,共4页
Medical Journal of Chinese People’s Health
