摘要
目的:观察膈下逐瘀汤合凉膈散联合常规西药治疗慢性胰腺炎急性发作期患者的效果。方法:选取2019年3月至2021年7月该院收治的86例慢性胰腺炎急性发作期患者进行前瞻性研究,按照随机数字表法分为观察组与对照组各43例。对照组采用常规西药治疗,观察组在对照组基础上联合膈下逐瘀汤合凉膈散治疗,比较两组疗效、临床指标(腹胀缓解时间、腹痛缓解时间、肠鸣音恢复时间、首次排气时间)水平、治疗前后血清炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-2和IL-6]水平和并发症发生率。结果:观察组治疗总有效率为93.02%,明显高于对照组的76.74%,差异有统计学意义(P<0.05);观察组腹胀缓解时间、腹痛缓解时间、肠鸣音恢复时间和首次排气时间均短于对照组,差异有统计学意义(P<0.05);治疗后,观察组TNF-α、IL-2、IL-6水平均低于对照组,差异有统计学意义(P<0.05);治疗期间,观察组并发症发生率为4.65%,明显低于对照组的18.60%,差异有统计学意义(P<0.05)。结论:膈下逐瘀汤合凉膈散联合常规西药治疗慢性胰腺炎急性发作期患者可提高疗效,缩短腹胀缓解时间、腹痛缓解时间、肠鸣音恢复时间和首次排气时间,降低其炎性因子水平和并发症发生率,效果优于单纯西药治疗。
Objective:To observe effects of Gexia Zhuyu decoction and Liangge powder combined with conventional western medicine in treatment of patients with acute episode of chronic pancreatitis.Methods:A prospective study was performed on 86 patients with acute episode of chronic pancreatitis who were admitted to this hospital from March 2019 to July 2021,and they were divided into observation group and control group according to the random number table method,43 cases in each.The control group was treated with conventional western medicine,while the observation group was treated with Gexia Zhuyu decoction and Liangge powder on the basis of that of the control group.The curative effects,the clinical index levels(abdominal distension relief time,abdominal pain relief time,bowel sound recovery time,first exhaust time),the serum inflammatory factor levels[tumor necrosis factor-α(TNF-α),interleukin(IL)-2 and IL-6]before and after treatment,and the incidence of complications were compared between the two groups.Results:The total effective rate of the observation group was 93.02%,which was significantly higher than 76.74%of the control group,and the difference was statistically significant(P<0.05).The abdominal distension relief time,the abdominal pain relief time,the bowel sound recovery time and the first exhaust time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of TNF-α,IL-2 and IL-6 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).During the treatment,the incidence of complications in the observation group was 4.65%,which was significantly lower than 18.60%in the control group,and the difference was statistically significant(P<0.05).Conclusions:Gexia Zhuyu decoction combined with Liangge powder combined with conventional western medicine can improve the curative effect in the treatment of the patients with acute episode of chronic pancreatitis,shorten the abdominal distension relief time,the abdominal pain relief time,the bowel sound recovery time and the first flatus time,and reduce the levels of inflammatory factors.and the incidence of complications.Moreover,it is superior to single western medicine treatment.
作者
王更磊
WANG Genglei(Emergency Department of Kaifeng Second Hospital of Traditional Chinese Medicine,Kaifeng 475000 Henan,China)
出处
《中国民康医学》
2022年第17期87-89,共3页
Medical Journal of Chinese People’s Health
关键词
膈下逐瘀汤
凉膈散
慢性胰腺炎
急性发作期
炎性因子
并发症
Gexia Zhuyu decoction
Liangge powder
Chronic pancreatitis
Acute episode period
Inflammatory factor
Complication
