摘要
目的 探讨脑循环治疗仪联合美金刚治疗阿尔茨海默病(AD)效果及对脑循环、血管修复因子的影响。方法 选取2018年1月—2021年1月北大医疗潞安医院神经内科收治AD患者111例临床资料,以随机数字表法分为对照组55例和研究组56例。对照组采取美金刚治疗,研究组在对照组基础上采取脑循环治疗仪治疗,均治疗1个月。比较2组治疗前后蒙特利尔认知量表(MoCA)、脑循环指标(左侧椎动脉、右侧椎动脉及基底动脉血流速度)、血管修复因子[血红素氧化酶-1(HO-1)、基质金属蛋白酶-9(MMP-9)、MMP-2]、神经递质[S100B蛋白、γ-氨基丁酸(GABA)、乙酰胆碱(Ach)]水平,以及不良反应发生情况。结果 治疗1个月后,研究组MoCA评分高于对照组(t/P=6.844/<0.001);左侧椎动脉、右侧椎动脉及基底动脉血流速度大于对照组(t/P=6.233/<0.001、10.110<0.001、5.661/<0.001);血清HO-1、GABA、Ach水平高于对照组(t/P=5.791/<0.001、5.664/<0.001、4.150/<0.001),MMP-9、MMP-2、S100B蛋白水平低于对照组(t/P=3.945/<0.001、3.640/<0.001、5.306/<0.001);2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 脑循环治疗仪联合美金刚应用于AD患者有助于改善微循环,恢复认知功能,机制可能与调节血管修复因子、神经递质有关,且安全性高。
Objective To investigate the effect of cerebral circulation therapeutic apparatus combined with memantine on Alzheimer’s disease(AD) and its influence on cerebral circulation and vascular repair factors.Methods From January 2018 to January 2021,111 patients with AD were selected from the Department of Neurology,Lu’an Hospital,Peking University Medical College.They were randomly divided into a control group of 55 patients and a study group of 56 patients.The control group was treated with memantine,and the study group was treated with cerebral circulation therapeutic apparatus on the basis of the control group,both of which were treated for 1 month.The Montreal Cognitive Scale(MoCA),cerebral circulation indexes(left vertebral artery,right vertebral artery and basilar artery blood flow velocity),vascular repair factors [heme oxygenase-1(HO-1),matrix metalloproteinase-9(MMP-9),MMP-2],neurotransmitter [S100 B protein γ-Aminobutyric acid(GABA),acetylcholine(Ach)],and adverse reactions.Results After 1 month treatment,the MoCA score of the study group was higher than that of the control group(t/P=6.844/0.05).Conclusion The application of cerebral circulation therapeutic apparatus combined with memantine in AD patients is helpful to improve microcirculation and restore cognitive function.The mechanism may be related to regulating vascular repair factors and neurotransmitters,with high safety.
作者
范彩芹
许海宁
何文杰
王星南
高莎莎
王国强
李俊飞
Fan Caiqin;Xu Haining;He Wenjie;Wang Xingnan;Gao Shasha;Wang Guoqiang;Li Junfei(Department of Neurology,Lu’an Hospital,Peking University Medical College,Changzhi 046200,China)
出处
《疑难病杂志》
CAS
2022年第10期1019-1023,共5页
Chinese Journal of Difficult and Complicated Cases
关键词
阿尔茨海默病
美金刚
脑循环治疗仪
脑循环
血管修复因子
作用机制
Alzheimer’s disease
Memantine
Cerebral circulation function therapy instrument
Cerebral circulation
Vascular repair factor
Mechanism
