摘要
目的探讨奥美拉唑钠联合特利加压素治疗肝硬化上消化道出血(UGB)的应用效果。方法选取2017年4月至2020年4月中国医科大学附属盛京医院沈阳雍森医院收治的78例肝硬化UGB患者作为研究对象,按照随机数字表法分为对照组(39例)与观察组(39例)。对照组患者采用奥美拉唑钠治疗,观察组在对照组基础上增用特利加压素治疗。比较两组患者的止血效果,谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(TBil)及活化部分凝血活酶时间(APTT)、血浆凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(FIB)水平。结果观察组患者输血量少于对照组,止血时间短于对照组,差异有统计学意义(P<0.05)。观察组治疗后的血红蛋白含量高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者TBil、ALT、AST水平低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者APTT、PT及TT均短于对照组,FIB水平高于对照组,差异有统计学意义(P<0.05)。结论对肝硬化UGB患者增用特利加压素,止血效果较好,还可以有效改善患者肝功能及凝血功能水平,值得推广和应用。
Objective To discuss application of Omeprazole Sodium combined with Teliressin on upper gastrointestinal bleeding(UGB)in cirrhosis.Methods A total of 78 patients with liver cirrhosis and UGB admitted to Shenyang Yongsen Hospital of Shengjing Hospital of China Medical University from April 2017 to April 2020 were selected as the research objects and divided into control group(39 cases)and observation group(39 cases)according to the random number table method.The control group was treated with Omeprazole Sodium,and the observation group was treated with Terlipressin on the basis of the control group.The hemostatic effect,aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBil),activated partial thromboplastin time(APTT),plasma prothrombin time(PT),prothrombin time(TT),fibrinogen(FIB)levels were compared between the two groups.Results The amount of blood transfusion in the observation group was less than that in the control group,and the hemostasis time was shorter than that in the control group,and the differences were statistically significant(P<0.05).The hemoglobin content in the observation group was higher than that in the control group after treatment,and the difference was statistically significant(P<0.05).After treatment,the levels of TBil,ALT and AST were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,APTT,PT and TT in the observation group were shorter than those in the control group,and FIB level was higher than that in the control group,and the differences were statistically significant(P<0.05).Conclusion The increased use of Teliressin in patients with UGB cirrhosis has good hemostasis effect,which can effectively improve the liver function and blood coagulation function.
作者
沈冰晶
SHEN Bingjing(Department of Emergency,Shenyang Yongsen Hospital of Shengjing Hospital of China Medical University,Liaoning Province,Shenyang110000,China)
出处
《中国当代医药》
CAS
2022年第30期57-59,63,共4页
China Modern Medicine
关键词
特利加压素
肝硬化上消化道出血
谷草转氨酶
谷丙转氨酶
总胆红素
活化部分凝血活酶时间
凝血酶原时间
凝血酶时间
Teliressin
Upper gastrointestinal bleeding in cirrhosis
Aspartate aminotransferase
Alanine aminotransferase
Total bilirubin
Activated partial thromboplastin time
Prothrombin time
Thrombin time
