摘要
目的比较不同年龄胃癌患者临床病理特征,为胃癌防治提供一定的参考依据。方法回顾性收集西部战区总医院2014年1月至2019年12月收治的698例胃癌患者的临床流行病学特征、病理类型和遗传学特征。根据患者年龄分为青年组(≤45岁,n=39)和中老年组(>45岁,n=659),比较两组在性别、肿瘤部位、病理类型、分化程度、浸润深度、脉管神经束侵犯、淋巴结转移、P53和人表皮生长因子受体-2(HER2)表达等方面的差异。结果698例胃癌患者年龄(62.25±10.15)岁,中位年龄64岁(23~87岁),男女性别比为3.20∶1.00。两组患者最常见的病理类型为腺癌;均以低分化为主;50%以上发生于胃下部;TNM分期以Ⅱ期多见;浸润深度以T3多见。中老年组肿瘤位于胃上部和TNM分期处于Ⅰ期的比例是青年组的3.0倍;两组患者性别比、病理类型和肿瘤部位比较,差异有统计学意义(P<0.05);肿瘤大小、分化程度、TNM分期、淋巴结转移、神经侵犯、脉管侵犯、浸润深度、P53表达和HER2表达方面比较,差异无统计学意义(P>0.05)。结论老年男性是胃癌的高发人群,不同年龄胃癌患者临床病理特征不同,青年组患者中女性更多见,印戒细胞癌发生率更高;中老年组患者肿瘤更易发生在胃上部,且多为Ⅰ期。
Objective To compare the clinicopathological characteristics of gastric cancer patients of different ages,so as to provide some reference for the prevention and treatment of gastric cancer.Methods The clinical epidemiological characteristics,pathological types and genetic characteristics of 698 patients with gastric cancer admitted to the General Hospital of Western Theater Command from January 2014 to December 2019 were retrospectively collected.Patients were divided into young group(≤45 years old,n=39)and middle-aged and elderly group(>45 years old,n=659)according to their age.The differences between the two groups in gender,tumor location,pathological type,degree of differentiation,depth of invasion,invasion of vascular nerve bundle,lymph node metastasis,expression of P53 and human epidermal growth factor receptor-2(HER2)were compared and statistically analyzed.Results The average age of 698 patients with gastric cancer was(62.25±0.15)years,the median age was 64 years(23~87 years),and the ratio of male to female was 3.20∶1.00.Adenocarcinoma was the most common pathological type in both groups.The tumors were mainly low differentiated,and more than 50%of them occurred in the lower part of the stomach.Most of the tumors were stageⅡin tumor node metastasis(TNM)staging and T3 in infiltration depth.The incidence of tumors located in the upper stomach and in TNM stageⅠin the middle-aged and elderly group was 3.0 times as much as that in the young group.There were statistically significant differences in gender ratio,pathological type and tumor location between the two groups(P<0.05).There were no significant differences in tumor size,differentiation degree,TNM stage,lymph node metastasis,nerve invasion,vascular invasion,invasion depth,P53 expression and HER2 expression(P>0.05).Conclusion Elderly men are the high risk population of gastric cancer.Patients with gastric cancer at different ages have different clinicopathological features.Women are more common in young patients,with a higher incidence of signet ring cell carcinoma.The tumors in middle-aged and elderly patients are more likely to occur in the upper stomach,and most of them are in stage I.
作者
杨湘雨
杨湘琳
杨岳峰
王骁
陈易华
李娟
Yang Xiangyu;Yang Xianglin;Yang Yuefeng;Wang Xiao;Chen Yihua;Li Juan(School of Clinic Medical Sciences,Chengdu Medical College,Chengdu 610500,China;School of Clinic Medical Sciences,North Sichuan Medical College,Nanchong 637100,China;School of Public Health,Chengdu Medical College,Chengdu 610500,China;Department of Pathology,General Hospital of Western Theater Command of PLA,Chengdu 610083,China;Department of Pathology and Pathophysiology,Chengdu Medical College,Chengdu 610500,China)
出处
《成都医学院学报》
CAS
2022年第5期578-582,共5页
Journal of Chengdu Medical College
基金
国家级大学生创新创业项目(No:S202013705007)
四川省省级大学生创新创业项目(No:S202013705072)
成都医学院调研类大学生创新创业项目(No:2020dy178)。
关键词
胃癌
临床病理特征
青年
中老年
Gastric cancer
Clinicopathological features
The young
The middle-aged and elderly
