摘要
目的 使用Meta分析的方法评价中药复方治疗椎间盘源性腰痛的有效性。方法 检索PubMed、中国知网、维普科技期刊数据库、万方数据库、Cochrane,根据Cochrane的标准,由2名研究者独立评估数据资料,纳入相关要素,并使用Review Manerger5.4对纳入研究行Meta分析。结果 严格按照纳排标准,最终纳入24项随机对照试验,共2 104例椎间盘源性腰痛患者(试验组1 054例、对照组1 050例)。Meta分析结果示:中药治疗在总有效率[RR=1.24,95%CI(1.18,1.31)]、4周及末次视觉模拟量表(VAS)评分[MD=-1.28,95%CI(-1.65,-0.90),P <0.00001;MD=-1.46,95%CI(-1.75,-1.18),P <0.00001]、4周及末次Oswestry功能障碍指数(ODI)评分[MD=-6.89,95%CI(-9.87,-3.91),P <0.00001;MD=-5.50,95%CI(-6.05,-4.96),P <0.00001]及日本骨科协会评估治疗量表(JOA)评分[(MD=4.15,95%CI(2.69,5.61),P <0.00001)]等方面,均优于对照组。结论单纯中药复方口服或联合其他疗法,均在缓解患者腰痛、改善腰椎功能以及提高生活质量方面有较为明显的优势,但仍需通过大样本量、高质量的随机对照试验进一步验证。
Objective:To evaluate the effectiveness of Chinese medicine compounds in the treatment of discogenic low back pain using a meta-analysis approach. Methods:PubMed,China National Knowledge Infrastructure(CNKI),VIP,Wanfang,and Cochrane were searched,and clinical data information was independently evaluated by two investigators according to the criteria established by Cochrane. Relevant elements were included,and the included studies were meta-analyzed using Review Manerger5.4. Results:24 randomized controlled trials with a total of 2 104 patients with discogenic low back pain(1 054 patients in the trial group and 1 050 patients in the control group) were finally included according to strict inclusion and exclusion criteria. Meta-analysis results showed that Chinese medicine compound treatment was more effective in total effective rate [RR=1.24,95%CI(1.18,1.31)],4-week and end VAS scores[MD=-1.28,95%CI(-1.65,-0.90),P < 0.00001;MD=-1.46,95%CI(-1.75,-1.18),P < 0.00001],4-week and final ODI scores[MD=-6.89,95%CI(-9.87,-3.91),P < 0.00001;MD=-5.50,95%CI(-6.05,-4.96),P < 0.00001]and JOA scores[(MD=4.15,95%CI(2.69,5.61),P < 0.00001)]were superior to the control group. Conclusion:Whether the Chinese medicine compound alone is taken orally or combined with other therapies,it has more obvious advantages in relieving patients′ low back pain,improving lumbar spine function and enhancing life treatment,but further validation through large sample size and high quality randomized controlled trials is still needed.
作者
汪松林
沈晓峰
徐波
张先达
刘昱江
周宇
张龙
陆斌杰
李宇卫
Wang Songlin;Shen Xiaofeng;Xu Bo;Zhang Xianda;Liu Yujiang;Zhou Yu;Zhang Long;Lu Binjie;Li Yuwei(Nanjing University f Chinese Medicine,Jiangsu,Nanjing 210023,China)
出处
《中国中医急症》
2022年第10期1698-1703,1712,共7页
Journal of Emergency in Traditional Chinese Medicine
基金
国家自然科学基金面上项目(82174399)
江苏省科技项目基础研究计划(自然科学基金)面上项目(BK20211084)
江苏省中医药管理局科技发展计划青年项目(QN202007)
苏州市科技局科技计划项目(SYS2020183)。
关键词
椎间盘源性腰痛
中药复方
META分析
随机对照试验
Discogenic low back pain
Chinese medicine compound
Meta-analysis
Randomized controlled trials
