摘要
目的探讨多囊卵巢综合征(PCOS)患者促排卵后的卵母细胞质量与胚胎发育潜能的关系。方法回顾性分析2019年1月至2021年12月在浙江省台州医院生殖医学中心接受体外受精(IVF)助孕的242例患者的临床资料。其中PCOS患者95例(PCOS组),单纯输卵管因素不孕患者147例(对照组)。两组患者均采用长方案或拮抗剂方案进行促排卵,比较两组患者获卵数、卵母细胞质量、胚胎发育等情况。结果PCOS组患者获卵数、成熟卵母细胞数、受精数、正常受精数、可利用胚胎数、囊胚数均多于对照组(均P<0.05),卵母细胞成熟率、正常受精率、卵裂率、优胚率、可利用胚胎率、囊胚形成率均低于对照组(均P<0.05),两组受精率和囊胚形成率比较差异均无统计学意义(均P>0.05)。结论PCOS患者因为窦卵泡基数多,获卵数等明显增加,但是卵母细胞成熟率等明显降低,说明卵母细胞质量和胚胎发育潜能受到了影响。
Objective To investigate the oocyte quality and embryo development potential in patients with polycystic ovary syndrome(PCOS) after ovulation induction. Methods The clinical data of 242 patients who underwent in vitro fertilization(IVF) in Reproductive Medicine Center of Taizhou Hospital of Zhejiang Province from January 2019 to December 2021 were retrospectively analyzed. There were 95 patients with PCOS(PCOS group) and 147 patients with simple tubal infertility(control group). Both groups were treated with long protocol or antagonist protocol for ovulation induction.The number of eggs obtained, oocyte quality and embryo development were compared between the two groups. Results Compared with the control group, the numbers of eggs obtained, metaphase Ⅱ oocytes(MⅡ), fertilization, normal fertilization, available embryos and blastocysts in the PCOS group were higher(all P<0.05). While the rates of oocyte maturation, normal fertilization, excellent embryo, available embryo and blastocyst formation were lower than those in the control group(all P<0.05). There were no significant difference in the fertilization, blastocyst formation rate(both P>0.05). Conclusion Due to the large number of sinus follicles, the number of eggs obtained is increased significantly in PCOS patients,but the quality of oocytes is low, which indicates that the low oocyte quality affects the embryo development potential in PCOS patients.
作者
蔡娇娇
杨欢利
陆文昊
沈秀珍
诸溢扬
CAI Jiaojiao;YANG Huanli;LU Wenhao;SHEN Xiuzhen;ZHU Yiyang(Reproductive Center,Taizhou Hospital of Zhejiang Province,Taizhou 317000,China)
出处
《浙江医学》
CAS
2022年第19期2094-2096,2100,共4页
Zhejiang Medical Journal
基金
台州恩泽医疗中心(集团)科学研究基金项目(17EZD4)。
关键词
多囊卵巢综合征
卵母细胞质量
胚胎发育潜能
Polycystic ovary syndrome
Oocyte quality
Embryo developmental potential
