摘要
目的:探讨四逆汤加减联合二甲双胍对2型糖尿病(T2DM)患者糖代谢及脂代谢的影响。方法:选取2019年1月至2021年12月合肥市第一人民医院内分泌科收治的T2DM患者112例作为研究对象,按照随机数字表法分为对照组(n=54)与观察组(n=59),对照组给予盐酸二甲双胍片,观察组在对照组基础上加用四逆汤加减治疗。比较2组患者临床疗效、空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、糖化血红蛋(HbA1c)、胆固醇(TC)、三酰甘油(TAG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、脑记忆功能评分及不良反应。结果:观察组总有效率高于对照组(P<0.05);治疗前,2组FBG、2 h PBG、HbA1c、TC、TAG、LDL-C、HDL-C水平比较,差异无统计学意义(P>0.05),治疗后,观察组FBG、2 h PBG、HbA1c、TC、TAG、LDL-C水平低于对照组,HDL-C水平高于对照组(P<0.05);观察组各维度脑记忆功能评分显著高于对照组(P<0.05);2组不良反应差异无统计学意义(P>0.05)。结论:四逆汤加减联合二甲双胍可有效降低T2DM患者血糖、血脂水平,提高患者生命质量,临床效果佳,不良反应少。
Objective:To investigate the effects of Sini Decoction combined with metformin on glucose metabolism and lipid metabolism in patients with type 2 diabetes mellitus(T2DM).Methods:A total of 112 T2DM patients who were admitted to the Department of Endocrinology of Hefei First People′s Hospital from January 2019 to December 2021 were selected and divided into a control group(54 cases)and an experimental group(59 cases)according to the random number table.The control group was given metformin hydrochloride tablets,while the experimental group was given modified Sini decoction on this basis.The clinical efficacy,fasting blood glucose(FBG),2 h postprandial blood glucose(2 h PBG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TAG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),brain memory function score and adverse reactions of the two groups were compared.Results:The total effective rate in the experimental group was higher than that in the control group(P<0.05).Before treatment,there was no significant difference in the levels of FBG,2 h PBG,HbA1c,TC,TAG,LDL-C and HDL-C between the two groups(P>0.05).After treatment,the levels of FBG,2 h PBG,HbA1c,TC,TAG and LDL-C in the experimental group were lower while the level of HDL-C was higher than those in the control group(P<0.05);in addition,each brain memory function score in the experiment was superior to that in the control group(P<0.05);no marked significance was observed in adverse reactions between the two groups(P>0.05).Conclusion:Sini Decoction combined with metformin could reduce the levels of blood glucose and blood lipids in T2DM patients and improve their quality of life,with good clinical effect and few adverse reactions.
作者
刘梦君
卢涛
覃彩孟
周玲玲
王春立
LIU Mengjun;LU Tao;QIN Caimeng;ZHOU Lingling;WANG Chunli(School of Life Sciences,Beijing University of Chinese Medicine,Beijing 100029,China;Department of Endocrinology,Hefei First People′s Hospital,Hefei 230000,China;Department of Endocrinology,The Second People′s Hospital of Hefei,Hefei 230000,China)
出处
《世界中医药》
CAS
2022年第18期2619-2622,2627,共5页
World Chinese Medicine
基金
国家自然科学基金面上项目(52173276)。
关键词
四逆汤
二甲双胍
2型糖尿病
糖代谢
脂代谢
不良反应
胰岛素
生命质量
Sini Decoction
Metformin
Type 2 diabetes mellitus
Glucose metabolism
Lipid metabolism
Adverse reactions
Insulin
Quality of life
