摘要
目的:研究伴咽喉反流病(LPRD)的胃食管反流病(GERD)患者中医证型及食管动力特点。方法:选取2018年1月—2021年8月就诊的159例GERD患者为研究对象,其中伴有LPRD者(观察组)79例,不伴有LPRD者(对照组)80例。均完成高分辨率食管测压检查,记录相关数据,比较两组患者的中医证型分布、食管动力之间的差异,采用SPSS 26.0软件进行统计分析。结果:中医证型比较:按5个中医证型(肝胃郁热证、胆热犯胃证、气郁痰阻证、中虚气逆证、脾虚湿热证)统计,两组比较差异有统计学意义(P<0.05);按实证、虚实夹杂证统计,两组比较差异无统计学意义(P>0.05)。食管动力指标比较:观察组上食管括约肌静息压、远端潜伏期高于对照组,实证观察组上食管括约肌静息压、远端潜伏期高于实证对照组,虚实夹杂证观察组弱蠕动百分率高于虚实夹杂证对照组(P<0.05)。食管动力障碍类型比较:观察组无效食管动力占比高于对照组(P<0.05)。结论:伴LPRD的GERD患者证型分布与对照组不同,以气郁痰阻证更为多见,上食管括约肌静息压更高,无效食管动力更多,且可能需要更长的时间去清除食管内容物,实证、虚实夹杂证存在着不同的食管动力特点。
Objective:To study Traditional Chinese Medicine(TCM)syndromes and characteristics of esophageal motility with gastroesophageal reflux disease(GERD)complicated with laryngopharyngeal reflux disease(LPRD).Methods:Seventy-nine patients complicated with LPRD(observation group)and eighty patients without LPRD(control group)were selected from January 2018 to August 2021,all patients underwent high resolution esophageal manometry,and the data were recorded.We compared the differences in the distribution of TCM syndrome types and esophageal motility between the two groups of patients.SPSS 26.0 software was used for statistical analysis.Results:In the aspect of TCM syndrome types,according to the five TCM syndrome types,there was statistical difference between the two groups(P<0.05).According to the excess syndrome and mingled syndrome types,there was no statistical difference between the two groups(P>0.05).In the aspect of esophageal motility,upper esophageal sphincter pressure and distal latency in the observation group were higher than those in the control group,and the excess syndrome observation group showed the same results as the excess syndrome control group,and percentage of weak peristalsis in the mingled syndrome observation group were higher than those in the mingled syndrome control group(P<0.05).In the aspect of esophageal motility disorder,the proportion of ineffective esophagus motility in the observation group was higher than that in the control group(P<0.05).Conclusion:The distribution of syndrome types in patients with GERD complicated with LPRD,is different from that in control group.In the patients with GERD complicated with LPRD,the syndrome of Qi stagnation and Phlegm obstruction is more common,and the upper esophageal sphincter pressure is higher,and the ineffective esophagus motility is more,and it may take longer to clear the contents of the esophagus.There are different esophageal motility characteristics between mingled syndrome and excess syndrome.
作者
王帅
陶琳
张声生
沈晨
郑瑛瑛
WANG Shuai;TAO Lin;ZHANG Shengsheng;SHEN Chen;ZHENG Yingying(igestive Disease Center,Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing 100010,China;Capital Medical University)
出处
《中国中西医结合消化杂志》
CAS
2022年第10期690-694,共5页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
首都卫生科研发展专项(No:首发2018-2-2231)。
关键词
咽喉反流病
胃食管反流病
中医证型
食管动力
laryngopharyngeal reflux disease
gastroesophageal reflux disease
Traditional Chinese Medicine syndromes
esophageal motility
