摘要
目的:探讨泼尼松联合西替利嗪对过敏性紫癜(HSP)患儿炎症反应及免疫功能的影响。方法:选取2018年6月~2021年6月来本院就诊的84例HSP患儿为研究对象,按照随机数字表法分为对照组和观察组,每组42例。对照组在常规治疗基础上给予醋酸泼尼松片治疗,观察组在对照组治疗基础上加用盐酸西替利嗪片,两组均连续治疗2周。比较两组症状缓解时间、炎症因子[白细胞介素-6(IL-6)、IL-8、肿瘤坏死因子α(TNF-α)]、免疫功能指标[免疫球蛋白A(IgA)、IgM、IgG]、不良反应发生率和随访6个月内的复发率。结果:观察组皮肤紫癜、胃肠道症状、关节症状等的缓解时间均短于对照组(P<0.05);治疗后两组血清IL-6、IL-8、TNF-α水平和血清IgA、IgM、IgG水平均降低,且观察组低于对照组(P<0.05);治疗期间两组不良反应发生率比较无统计学差异(P>0.05);治疗完成后随访6个月,观察组复发率(2例,4.76%)低于对照组(6例,14.29%),但组间比较无统计学差异(χ^(2)=1.243,P=0.265)。结论:泼尼松联合西替利嗪治疗可有效减轻HSP患儿炎症反应、调节免疫指标、加快症状缓解,且安全性较高。
Objective:To investigate effect of prednisone complicated with cetirizine on inflammatory response and immune function in children with Henoch-Schönlein purpura(HSP).Methods:A total of 84 patients with HSP who came to our hospital from June 2018 to June 2021 were selected as the research objects,and were divided into the control group and the observation group according to the random number table,with 42 patients in each group.The control group was treated with prednisone acetate tablets on the basis of conventional treatment,and the observation group was treated with cetirizine hydrochloride tablets on the basis of the control group.Both groups were treated continuously for 2 week.The symptom relief time,infl ammatory factors[interleukin-6(IL-6),IL-8,tumor necrosis factorα(TNF-α)],immune function indicators[immunoglobulin A(IgA),IgM,IgG],adverse reaction rate and recurrence rate within 6 months of follow-up were compared between the two groups.Results:The relief time of skin purpura,gastrointestinal symptoms and joint symptoms in the observation group was shorter than those in the control group(P<0.05).After treatment,the levels of serum IL-6,IL-8,TNF-αand serum IgA,IgM,IgG in the two groups decreased,and the levels in the observation group were lower than those in the control group(P<0.05).There was no statistical diff erence in the incidence of adverse reactions between the two groups during treatment(P>0.05).Follow up for 6 months after treatment,the recurrence rate in the observation group(2 cases,4.76%)was lower than that in the control group(6 cases,14.29%),but there was no statistical diff erence between the groups(χ^(2)=1.243,P=0.265).Conclusion:Prednisone combined with cetirizine can eff ectively reduce the infl ammatory reaction,regulate immune indicators,and accelerate symptom relief in children with HSP.It has high safety.
作者
武海江
孙永法
陈清
WU Hai-jiang;SUN Yong-fa;CHEN Qing(Department of Pediatrics,Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang 471009,China)
出处
《中国合理用药探索》
2022年第10期69-74,共6页
Chinese Journal of Rational Drug Use
基金
河南省医学科技攻关计划联合共建项目(LHGJ20191212)。
关键词
过敏性紫癜
泼尼松
西替利嗪
炎症反应
免疫
Henoch-Schönlein purpura
prednisone
cetirizine
infl ammatory response
immune
