摘要
循环肿瘤细胞(CTC)检测技术作为一种无创的肿瘤辅助诊断工具,可以应用于肿瘤的早期诊断、耐药监测、疗效评估、预后判断及个体化治疗,在肿瘤的复发及转移中具有重要的研究意义。但是如何对CTC进行有效的富集鉴定是影响技术研究应用的重要因素。针对以上问题,该文对CTC的鉴定分析方法及应用现状及进展进行综述。
As a non-invasive auxiliary diagnostic tool for tumors,circulating tumor cell(CTC)detection technology can be applied to early diagnosis,drug resistance monitoring,efficacy evaluation,prognosis judgment and individualized treatment of tumors.It has important research significance in tumor recurrence and metastasis.However,how to effectively enrich and identify CTC is an important factor affecting the application of technology research.In view of the above problems,this paper reviews the current status and progress of the identification and analysis methods of CTC and their applications.
作者
马莹(综述)
宁大为
于华杰
王振丹
李胜
夏梅
李浩(审较)
MA Ying;NING Dawei;YU Huajie;WANG Zhendan;LI Sheng;XIA Mei;LI Hao(Shandong Pharmaceutical Research Institute,Jinan,Shandong 250062,China;Department of Liver and Gallbladder Surgery,Affiliated Tumor Hospital of Shandong First Medical University/Shandong Cancer Hospital and Institute/Shandong Cancer Hospital,Jinan,Shandong 250117,China;Shandong First Medical University/Shandong Academy of Medical Sciences,Jinan,Shandong 250117,China;Department of Emergency Surgery,Zhangqiu District People′s Hospital,Jinan,Shandong 250200,China)
出处
《国际检验医学杂志》
CAS
2022年第21期2665-2669,共5页
International Journal of Laboratory Medicine
基金
2019年度济南市“高校20条”项目(2019GXRC020)
山东第一医科大学学术提升计划项目(2019QL004)
泰山学者工程专项经费资助(ts20190952)。
关键词
循环肿瘤细胞
分子特征
鉴定分析
circulating tumor cell
molecular characteristics
appraisal analysis
