摘要
目的 研究低频重复经颅磁刺激(rTMS)治疗对急性缺血性脑卒中后抑郁(PSD)患者5-羟吲哚乙酸(5-HIAA)、氨基酸类神经递质[谷氨酸(Glu)、天冬氨酸(Asp)、甘氨酸(Gly)、γ-氨基丁酸(GABA)]及5-羟色胺(5-HT)的影响。方法 选取2021年1月至2021年12月宜兴市人民医院收治的88例急性缺血性PSD患者的临床资料进行分析,分为研究组(n=45,常规治疗结合低频重复经颅磁刺激治疗)和对照组(n=43,常规治疗),比较两组临床疗效、5-HIAA、神经递质、5-HT及不良反应。结果 研究组总有效率(93.33%)高于对照组(76.74%),差异有统计学意义(P<0.05)。治疗后研究组Glu、Asp低于对照组,Gly、GABA、5-HIAA、5-HT高于对照组,差异均有统计学意义(P<0.05)。研究组不良反应率(13.33%)与对照组(11.63%)比较差异无统计学意义(P>0.05)。结论 r TMS治疗可有效提升急性缺血性脑卒中后抑郁患者的临床疗效,对患者神经递质等改善效果良好,且安全性高。
Objective To study the effecsts of low-frequency repetitive transcranial magnetic stimulation(rTMS)on 5-Hydroxyindole-acetic acid(5-HIAA),neurotransmitter[glutamic acid(Glu),L-aspartic acid(Asp),glycine(Gly),γ-Aminobutyrie Acid(GABA)]and 5-hydroxytryptamine(5-HT)in patients with acute ischemic post-stroke depression(PSD). Methods The clinical data of 88 patients with acute ischemic PSD who were admitted toYixing People’s Hospital from January 2021 to December 2021 were selected for analysis. According to different treatment,they were divided into the study group(n=45,conventional treatment combined with low-frequency repetitive transcranial electrical stimulation)and the control group(n=43,conventional treatment),5-HIAA,neurotransmitter,5-HT and adverse reactions were compared between the two groups. Results The total effective rate in the study group(93.33%)was higher than that in the control group(76.74%),and the difference was statistically significant(P<0.05). After treatment,the Glu and Asp in the study group were lower than those in the control group,while the levels of Gly,GABA,5-HIAA and 5-HT in the study group were higher than those in the control group,and the difference was statistically significant(P<0.05). There was no significant difference in the adverse reaction rate between the study group(13.33%)and the control group(11.63%)(P>0.05). Conclusion r TMS treatment can effectively improve the clinical efficacy of patients with acute ischemic post-stroke depression,and has a good improvement effect on neurotransmitters,which has high safety.
作者
秦雅鑫
张恒
闵白媛
许冬华
花志娟
QIN Yaxin;ZHANG Heng;MIN Baiyuan;XU Donghua;HUA Zhijuan(Department of Rehabilitation Medicine,Yixing People's Hospital,Yixing,Jiangsu,China,214200;Department of Neurology,Yixing People's Hospital,Yixing,Jiangsu,China,214200;Department of Rehabilitation Medicine,Jiurucheng Rehabilitation Hospital,Yixing,Jiangsu,China,214206)
出处
《分子诊断与治疗杂志》
2022年第10期1741-1744,共4页
Journal of Molecular Diagnostics and Therapy
基金
江苏省卫健委指导性项目(Z2021001)
无锡市“双百”中青年医疗卫生拔尖人才项目(BJ2020108)。
