摘要
对生命早期原核细胞内遗传信息传递法则的形成过程进行推演是一项值得探索的工作.基于地球诞生初期所可能存在的理化条件及演化,提出了生物小分子产生的化学必然性以及籍此促使生物大分子产生并呈现生命端倪的逻辑必然性.在提出不同原始反应之间维持相对平衡观点的基础上,分析了产生结构相对稳定、对体系危害程度小的生物大分子以及大分子聚集体的成因及重要意义,阐释了囊泡(类细胞结构)的形成机制与意义;基于模板反应,提出了“软模板”(即mRNA)与“硬合成装置”(即核糖体)进行蛋白质合成时的相互筛选(即柔-刚对接模型)以及多种RNA参与蛋白质生物合成的成因,籍此提出了囊泡内因长期演化所导致的“弱遗传关系”的模型.同时,也从逻辑学的视角分析了DNA与RNA形成先后的问题、蛋白质与核酸形成先后问题、病毒进化与细胞进化之关系等关乎生命起源与进化的重要科学问题.最后,对生命起源的逻辑、生命现象的重新定义等问题进行了讨论.
It’s one valuable work to deduce the establishment process of genetic information transmission rule in prokaryote cell from early life origin.According to the physical and chemical condition and evolution existed possibly in early stage after Earth birth,the chemical inevitability of forming small biological molecular and the logical inevitability of forming biomacromolecule and showing clue of life were proposed in this paper.Firstly,based the proposal views of keeping relative balance among those original chemical reactions,the reasons and significance were analyzed for the relative stabilization of biomacromolecule structure,little harm to involved system and its congeries cause of formation.And the forming mechanism of vesicula(structure of cell-like)and its significance were also elucidated.Then,based on template reaction,an inter-chose(Model of Soft-Hard Buttjoint)between the“soft template”(mRNA)and“hard synthesizing structure”(ribosome)was presented in synthesizing protein and the reason was also proposed for many sorts of RNA introduced in protein synthesis.Subsequently a mode of“weak genetic relationship”formed from long time evolution in vesicular was presented.And then,several important scientific topics on the origin of life and evolution were analyzed from the Logic angle,including early or late of DNA and RNA formation,early or late of protein and nucleic acid formation and the relation of Virus evolution and Cell evolution etc.Finally,the logic of life origin and redefinition of life phenomenon etc.were discussed.
作者
赵东旭
冯永君
王丰
张金凤
ZHAO Dongxu;FENG Yongjun;WANG Feng;ZHANG Jinfeng(School of Life Science,Beijing Institute of Technology,Beijing 100081,China)
出处
《北京理工大学学报》
EI
CAS
CSCD
北大核心
2022年第11期1105-1126,共22页
Transactions of Beijing Institute of Technology
基金
国家自然科学基金资助项目(32071269)
中国学位与研究生教育学会2020年研究课题(2020MSA)。
关键词
生命起源与演化
非生物合成
中心法则
弱遗传关系
生化反应平衡
origin of life and evolution
abiotic synthesis
genetic central dogma
weak genetic relationship
balance of chemical reactions
